PMID- 2249017
OWN - NLM
STAT- MEDLINE
DCOM- 19910114
LR  - 20091111
IS  - 0007-4551 (Print)
IS  - 0007-4551 (Linking)
VI  - 77
IP  - 10
DP  - 1990
TI  - [Prognostic value of thymidine kinase in cancer of the breast].
PG  - 973-83
AB  - We have measured by a radioenzymatic assay the thymidine kinase in the cytosol of 
      182 primary infiltrating breast cancers. Maximal follow-up is 95 months. 
      Thymidine kinase was found to be related to SBR grade, tumour size and absence of 
      oestradiol receptors (RE). Univariate analysis has pointed out a significant 
      linkage between overall or metastase free survival and thymidine kinase, using a 
      cut-off level of 80 mU/mg protein which is the most discriminating value. 
      Thymidine kinase appeared to be particularly useful in lymph-node-positive, 
      RE-negative and grade 3 patients. Multivariate analysis of the overall survival 
      and of the metastase free survival (Cox model) revealed that they were strongly 
      related to thymidine kinase status.
FAU - Romain, S
AU  - Romain S
AD  - Laboratoire d'oncologie biologique-biopathologie tissulaire, faculte de medecine 
      de Marseille-secteur nord, France.
FAU - Javre, J L
AU  - Javre JL
FAU - Samperez, S
AU  - Samperez S
FAU - Jouan, P
AU  - Jouan P
FAU - Bressac, C
AU  - Bressac C
FAU - Varette, I
AU  - Varette I
FAU - Brandone, H
AU  - Brandone H
FAU - Martin, P M
AU  - Martin PM
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Valeur pronostique de la thymidine kinase dans le cancer du sein.
PL  - France
TA  - Bull Cancer
JT  - Bulletin du cancer
JID - 0072416
RN  - 0 (Receptors, Estradiol)
RN  - 0 (Receptors, Progesterone)
RN  - EC 2.7.1.21 (Thymidine Kinase)
SB  - IM
MH  - Axilla
MH  - Breast Neoplasms/*enzymology/mortality/pathology
MH  - Cytosol/enzymology
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Lymphatic Metastasis
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Prognosis
MH  - Receptors, Estradiol/analysis
MH  - Receptors, Progesterone/analysis
MH  - Survival Analysis
MH  - Thymidine Kinase/analysis/*metabolism
EDAT- 1990/01/01 00:00
MHDA- 1990/01/01 00:01
CRDT- 1990/01/01 00:00
PHST- 1990/01/01 00:00 [pubmed]
PHST- 1990/01/01 00:01 [medline]
PHST- 1990/01/01 00:00 [entrez]
PST - ppublish
SO  - Bull Cancer. 1990;77(10):973-83.