PMID- 22490584
OWN - NLM
STAT- MEDLINE
DCOM- 20120803
LR  - 20120411
IS  - 2542-5641 (Electronic)
IS  - 0366-6999 (Linking)
VI  - 125
IP  - 5
DP  - 2012 Mar
TI  - Somatosensory disinhibition in patients with paroxysmal kinesigenic dyskinesia.
PG  - 838-42
AB  - BACKGROUND: Paroxysmal kinesigenic dyskinesia (PKD) is characterized by recurrent 
      brief episodes of chorea and dystonia induced by sudden movement. Whether the 
      central nervous system is hyper- or hypoexcitable in PKD remains undetermined. 
      The aim of our study was to compare the somatosensory evoked potential (SEP) 
      recovery cycle, a marker of somatosensory system excitability, in PKD patients 
      and controls. METHODS: Twenty-four PKD patients (mean age of (20.0+/-5.3) years; 21 
      males, 3 females) and 18 control age-matched subjects (mean age of (22.0+/-5.0) 
      years; 17 males, 1 female) were studied. The stimuli were delivered to the median 
      nerve in the affected dominant arm in patients and in the dominant arm in 
      controls. The change in SEP amplitude was measured after paired electrical 
      stimulation at interstimulus intervals (ISIs) of 5, 20, and 40 ms. The SEPs 
      evoked by S2 (test stimulus) were calculated by subtracting the response to S1 
      (the conditioning stimulus) from the response to a pair of stimuli (S1+S2), and 
      their amplitudes were compared with those of the control response (S1) at each 
      ISI. Analysis of variance (ANOVA) or equivalent was used for non-parametric data. 
      RESULTS: In patients, the P27 amplitude after the single stimulus (S1) was 
      significantly larger than that after the control stimulus. The (S2/S1)x100 ratio 
      for P14 and N30 SEPs did not differ significantly between PKD patients and normal 
      subjects at ISI of 5 ms but were significantly higher in patients at ISIs of 20 
      and 40 ms (P<0.05). CONCLUSIONS: Somatosensory system disinhibition takes place 
      in PKD. The finding of reduced suppression of different SEPs, each thought to 
      have a different origin, suggests an abnormality of intracortical and subcortical 
      inhibitory circuits.
FAU - Wei, Hua
AU  - Wei H
AD  - Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 
      100053, China.
FAU - Sun, Ying
AU  - Sun Y
FAU - Chen, Hai
AU  - Chen H
FAU - Wang, De-quan
AU  - Wang DQ
FAU - Li, Li-ping
AU  - Li LP
FAU - Ding, Yan
AU  - Ding Y
FAU - Liu, Ai-hua
AU  - Liu AH
FAU - Lu, Chang-feng
AU  - Lu CF
FAU - Wang, Yu-ping
AU  - Wang YP
LA  - eng
PT  - Journal Article
PL  - China
TA  - Chin Med J (Engl)
JT  - Chinese medical journal
JID - 7513795
RN  - Familial paroxysmal dystonia
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Case-Control Studies
MH  - Dystonia/*physiopathology
MH  - Evoked Potentials, Somatosensory/*physiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Young Adult
EDAT- 2012/04/12 06:00
MHDA- 2012/08/04 06:00
CRDT- 2012/04/12 06:00
PHST- 2012/04/12 06:00 [entrez]
PHST- 2012/04/12 06:00 [pubmed]
PHST- 2012/08/04 06:00 [medline]
PST - ppublish
SO  - Chin Med J (Engl). 2012 Mar;125(5):838-42.