PMID- 22490596
OWN - NLM
STAT- MEDLINE
DCOM- 20120803
LR  - 20120411
IS  - 2542-5641 (Electronic)
IS  - 0366-6999 (Linking)
VI  - 125
IP  - 5
DP  - 2012 Mar
TI  - A high-fat diet reverses improvement in glucose tolerance induced by 
      duodenal-jejunal bypass in type 2 diabetic rats.
PG  - 912-9
AB  - BACKGROUND: Bariatric surgery offers successful resolution of type 2 diabetes 
      mellitus (T2DM). However, recurrence of T2DM has been observed in a number of 
      patients with initial resolution after bariatric surgery. This study aimed to 
      induce reversal of the improvement of diabetes in T2DM rats after 
      duodenal-jejunal bypass (DJB), and identify the effects of weight changes and gut 
      hormones that might be involved. METHODS: DJB surgery was performed in two T2DM 
      rat models (n=20 for each group): non-obese Goto-Kakizaki (GK) rats, and 
      moderately-obese T2DM rats induced by a combination of a high-fat diet (HFD) and 
      low-dose streptozotocin (HS rats). The controls were sham-operated and 
      non-treated rats. All rats were then randomly divided into HFD- and low-fat diet 
      (LFD)-fed groups. Glucose tolerance, insulin tolerance, glucose-stimulated 
      insulin, glucagon-like peptide-1 (GLP-1) and peptide YY (PYY) secretion, food 
      intake and body weight were measured and compared with controls. RESULTS: DJB 
      surgery resulted in a significant improvement in glucose tolerance in both GK and 
      HS rats fed with either HFD or LFD. In contrast to LFD-fed rats, improved glucose 
      tolerance was impaired in GK and HS rats fed with an HFD, accompanied by 
      re-impairment of insulin tolerance and failure in enhancement of insulin 
      secretion. There was no significant difference in food intake and body weight 
      between DJB-operated and control rats, and between HFD- and LFD-fed rats. 
      Glucose-stimulated GLP-1 and PYY levels were significantly increased after DJB 
      surgery; however, they were not significantly different between HFD- and LFD-fed 
      rats. CONCLUSION: An HFD reverses the improvement in glucose tolerance induced by 
      DJB surgery in T2DM rats, primarily ascribing to the re-impairment of insulin 
      sensitivity, but does not change body weight, GLP-1 and PYY levels.
FAU - Liu, Shao-zhuang
AU  - Liu SZ
AD  - Department of General Surgery, Qilu Hospital of Shandong University, Experimental 
      Center, School of Chemistry and Chemical Engineering, Shandong University, Jinan, 
      Shandong 250012, China.
FAU - Sun, Dong
AU  - Sun D
FAU - Zhang, Guang-yong
AU  - Zhang GY
FAU - Wang, Lei
AU  - Wang L
FAU - Liu, Teng
AU  - Liu T
FAU - Sun, Yu
AU  - Sun Y
FAU - Li, Ming-xia
AU  - Li MX
FAU - Hu, San-yuan
AU  - Hu SY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Chin Med J (Engl)
JT  - Chinese medical journal
JID - 7513795
RN  - 0 (Blood Glucose)
SB  - IM
MH  - Animals
MH  - Blood Glucose/drug effects
MH  - Diabetes Mellitus, Type 2/blood/*chemically induced/pathology/*surgery
MH  - Diet, High-Fat/*adverse effects
MH  - *Gastric Bypass
MH  - Glucose Tolerance Test
MH  - Male
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 2012/04/12 06:00
MHDA- 2012/08/04 06:00
CRDT- 2012/04/12 06:00
PHST- 2012/04/12 06:00 [entrez]
PHST- 2012/04/12 06:00 [pubmed]
PHST- 2012/08/04 06:00 [medline]
PST - ppublish
SO  - Chin Med J (Engl). 2012 Mar;125(5):912-9.