PMID- 22490691
OWN - NLM
STAT- MEDLINE
DCOM- 20121231
LR  - 20120411
IS  - 0376-2491 (Print)
IS  - 0376-2491 (Linking)
VI  - 92
IP  - 2
DP  - 2012 Jan 10
TI  - [Risks of type 2 diabetes mellitus and impaired glucose regulation among elderly 
      patients with essential hypertension: a 10-years cohort study].
PG  - 102-5
AB  - OBJECTIVE: To explore the incidence of type 2 diabetes mellitus (T2DM) and 
      impaired glucose regulation (IGR) among elderly patients with and without 
      hypertension during a follow-up period of 10 years. METHODS: The subjects were 
      elderly patients (> 60 years old) undergoing annual health examinations at our 
      hospital. And the previously diagnosed T2DM and IGR patients were excluded. And 
      the incidence and risk factors were analyzed by Kaplan-Meier method and COX's 
      proportional hazard. RESULTS: Among a total of 1136 subjects, 582 were enrolled. 
      They were divided into essential hypertension group (HT, n = 384) and 
      non-essential hypertension group (NHT, n = 198) (including new-onset 67 
      subjects). During a 10-year follow-up, the incidence of new-onset diabetes was 
      27.6% in HT group and 18.7% in NHT group (HR = 1.48; 95%CI: (1.07 - 2.04), P < 
      0.05). And the incidence density of T2DM were 33.8 per thousand and 20.6 per thousand respectively in two 
      groups. There was no difference in the prevalence of IGR among HT and NHT groups 
      and no difference was found in the prevalence of T2DM or IGR among new-onset HT 
      and NHT groups. The independent risk factors of T2DM was dyslipidemia (HR = 
      1.459; 95%CI: 1.027 - 2.072, P < 0.05) and hypertension (HR = 1.516; 95%CI: 1.039 
      - 2.212, P < 0.05) based upon the COX's proportional hazard analysis. 
      Dyslipidemia (HR = 1.545; 95%CI: 1.087 - 2.195, P < 0.05) and hypertension (HR = 
      1.524; 95%CI: 1.044 - 2.224, P < 0.05) were also independent risk factors of 
      abnormal glycometabolism (T2DM and IGR). Kaplan-Meier analysis indicated that the 
      accumulative incidence of DM and abnormal glycometabolism was different between 
      the HT and NHT groups. CONCLUSION: The DM risk is 1.516 folds higher in elderly 
      patients with HT than in those without. According to multivariate analysis, 
      hypertension and dyslipidemia are independent risk factors of T2DM and abnormal 
      glycometabolism (T2DM and IGR).
FAU - Li, Yu-peng
AU  - Li YP
AD  - Department of Geriatric Endocrinology, PLA General Hospital, Beijing, China.
FAU - Shao, Ying-hong
AU  - Shao YH
FAU - Tian, Hui
AU  - Tian H
FAU - Fang, Fu-sheng
AU  - Fang FS
FAU - Sun, Ban-ruo
AU  - Sun BR
FAU - Xiao, Jing
AU  - Xiao J
FAU - Pei, Yu
AU  - Pei Y
FAU - Yan, Shuang-tong
AU  - Yan ST
FAU - Han, Xiao-fei
AU  - Han XF
FAU - Li, Chen-xi
AU  - Li CX
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Yi Xue Za Zhi
JT  - Zhonghua yi xue za zhi
JID - 7511141
RN  - 0 (Blood Glucose)
SB  - IM
MH  - Aged
MH  - Blood Glucose/metabolism
MH  - Cohort Studies
MH  - Diabetes Mellitus, Type 2/*epidemiology/metabolism
MH  - Female
MH  - Glucose Intolerance/*epidemiology
MH  - Humans
MH  - Hypertension/*epidemiology
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Proportional Hazards Models
MH  - Prospective Studies
MH  - Risk Factors
EDAT- 2012/04/12 06:00
MHDA- 2013/01/01 06:00
CRDT- 2012/04/12 06:00
PHST- 2012/04/12 06:00 [entrez]
PHST- 2012/04/12 06:00 [pubmed]
PHST- 2013/01/01 06:00 [medline]
PST - ppublish
SO  - Zhonghua Yi Xue Za Zhi. 2012 Jan 10;92(2):102-5.