PMID- 22492720 OWN - NLM STAT- MEDLINE DCOM- 20121207 LR - 20120704 IS - 1520-7560 (Electronic) IS - 1520-7552 (Linking) VI - 28 IP - 5 DP - 2012 Jul TI - Birth weight in newborn infants with different diabetes-associated HLA genotypes in three neighbouring countries: Finland, Estonia and Russian Karelia. PG - 455-61 LID - 10.1002/dmrr.2303 [doi] AB - BACKGROUND: Human leukocyte antigen (HLA) genotypes associated with increased risk for type 1 diabetes mellitus (T1D) have been reported to be associated with increased birth weight. We set out to investigate the association between HLA haplotypes conferring risk for T1D and birth weight and search for possible differences in the strength of these associations among populations with contrasting incidence of T1D. METHODS: As a part of the EU-funded DIABIMMUNE study, genotyping for the HLA haplotypes associated with T1D was performed in 8369 newborn infants from Estonia, Finland and Russian Karelia. Infants born before 35 gestational weeks, from mothers with diabetes, and multiple pregnancies were excluded. Relative birth weight, expressed in standard deviation scores, was estimated for each gestational week, sex and country. The standard deviation scores were calculated internally using the actual population studied. According to their HLA haplotypes, participants were divided into risk groups, and the distribution of birth weight between quartiles was analysed. RESULTS: We did not find any direct association between various HLA risk-associated genotypes (HLA DR3-DQ2/DR4-DQ8, DR3-DQ2/X or DR4-DQ8/X) and birth weight. We observed a significant relationship between increased relative birth weight and the protective HLA-DR2-DQ6 and DR13-DQ6 haplotypes. This association was significant only when these haplotypes were found together with the DR4-DQ8 haplotype. CONCLUSIONS: The previously reported association between HLA-risk haplotypes for T1D and an increased birth weight was not confirmed. This suggests that the mechanisms behind the association between high birth weight and risk for T1D may be not directly HLA related. CI - Copyright (c) 2012 John Wiley & Sons, Ltd. FAU - Peet, Aleksandr AU - Peet A AD - Department of Pediatrics, University of Tartu, Tartu, Estonia. aleksandr.peet@kliinikum.ee FAU - Kool, Pille AU - Kool P FAU - Ilonen, Jorma AU - Ilonen J FAU - Knip, Mikael AU - Knip M FAU - Tillmann, Vallo AU - Tillmann V CN - DIABIMMUNE Study Group LA - eng PT - Journal Article PT - Multicenter Study PT - Research Support, Non-U.S. Gov't DEP - 20120410 PL - England TA - Diabetes Metab Res Rev JT - Diabetes/metabolism research and reviews JID - 100883450 RN - 0 (HLA Antigens) SB - IM MH - Adult MH - Birth Weight/*genetics MH - Diabetes Mellitus, Type 1/epidemiology/*genetics MH - Estonia/epidemiology MH - Female MH - Finland/epidemiology MH - *Genetic Predisposition to Disease MH - Genotype MH - HLA Antigens/*genetics MH - Haplotypes/*genetics MH - Humans MH - Infant MH - Infant, Newborn MH - Male MH - Russia/epidemiology MH - Young Adult FIR - Koski, Katriina IR - Koski K FIR - Koski, Matti IR - Koski M FIR - Harkonen, Taina IR - Harkonen T FIR - Ryhanen, Samppa IR - Ryhanen S FIR - Hamalainen, Anu-Maaria IR - Hamalainen AM FIR - Ormisson, Anne IR - Ormisson A FIR - Ulich, Valentina IR - Ulich V FIR - Kuzmicheva, Elena IR - Kuzmicheva E FIR - Mokurov, Sergei IR - Mokurov S FIR - Markova, Svetlana IR - Markova S FIR - Pylova, Svetlana IR - Pylova S FIR - Isakova, Marina IR - Isakova M FIR - Shakurova, Elena IR - Shakurova E FIR - Petrov, Vladimir IR - Petrov V FIR - Dorshakova, Natalya V IR - Dorshakova NV FIR - Karapetyan, Tatyana IR - Karapetyan T FIR - Varlamova, Tatyana IR - Varlamova T FIR - Kiviniemi, Minna IR - Kiviniemi M FIR - Alnek, Kristi IR - Alnek K FIR - Janson, Helis IR - Janson H FIR - Uibo, Raivo IR - Uibo R FIR - Salum, Tiit IR - Salum T FIR - von Mutius, Erika IR - von Mutius E FIR - Weber, Juliane IR - Weber J FIR - Ahlfors, Helena IR - Ahlfors H FIR - Kallionpaa, Henna IR - Kallionpaa H FIR - Laajala, Essi IR - Laajala E FIR - Lahesmaa, Riitta IR - Lahesmaa R FIR - Lahdesmaki, Harri IR - Lahdesmaki H FIR - Moulder, Robert IR - Moulder R FIR - Nieminen, Janne IR - Nieminen J FIR - Ruohtula, Terhi IR - Ruohtula T FIR - Vaarala, Outi IR - Vaarala O FIR - Honkanen, Hanna IR - Honkanen H FIR - Hyoty, Heikki IR - Hyoty H FIR - Kondrashova, Anita IR - Kondrashova A FIR - Oikarinen, Sami IR - Oikarinen S FIR - Harmsen, Hermie J M IR - Harmsen HJ FIR - De Goffau, Marcus C IR - De Goffau MC FIR - Welling, Gjalt IR - Welling G FIR - Alahuhta, Kirsi IR - Alahuhta K FIR - Virtanen, Suvi M IR - Virtanen SM FIR - Knip, Mikael IR - Knip M FIR - Ryhanen, Samppa IR - Ryhanen S FIR - Peet, Aleksandr IR - Peet A FIR - Tillmann, Vallo IR - Tillmann V FIR - Ilonen, Jorma IR - Ilonen J EDAT- 2012/04/12 06:00 MHDA- 2012/12/12 06:00 CRDT- 2012/04/12 06:00 PHST- 2012/04/12 06:00 [entrez] PHST- 2012/04/12 06:00 [pubmed] PHST- 2012/12/12 06:00 [medline] AID - 10.1002/dmrr.2303 [doi] PST - ppublish SO - Diabetes Metab Res Rev. 2012 Jul;28(5):455-61. doi: 10.1002/dmrr.2303. Epub 2012 Apr 10.