PMID- 22494702 OWN - NLM STAT- MEDLINE DCOM- 20130506 LR - 20220321 IS - 1872-7123 (Electronic) IS - 0165-1781 (Linking) VI - 199 IP - 3 DP - 2012 Oct 30 TI - Neurotrophic factors in obsessive-compulsive disorder. PG - 195-200 LID - S0165-1781(12)00143-6 [pii] LID - 10.1016/j.psychres.2012.03.034 [doi] AB - In this cross-sectional study, we assessed the levels of neurotrophins (NF) of patients with obsessive-compulsive disorder (OCD) in different stages of treatment and their relationship with OCD clinical features. Forty patients with OCD and 40 healthy controls had Brain-Derived Neurotrophic Factor (BDNF), Nerve Growth Factor (NGF), and Glial Cell-Derived Neurotrophic Factor (GNDF) plasma levels measured by enzyme-linked immunosorbent assay (ELISA). Patients with OCD were further examined with the Obsessive-Compulsive Inventory-Revised, the Beck Depression Inventory, the Beck Anxiety Inventory, and the Sheehan Disability Scale (SDS). Patients with OCD exhibited significantly lower levels of BDNF and significantly increased levels of NGF as compared to healthy controls. In OCD, statistically significant negative correlations between BDNF levels and number of working days lost per week were found. Additional analyses revealed a statistically significant positive correlation between both NGF and GDNF and severity of washing symptoms. Plasma levels of NF were not affected by age, age at OCD onset, gender, major depressive disorder, the relative dose of serotonin-reuptake inhibitors being prescribed, or the use of antipsychotics. Our findings suggest that patients with OCD may exhibit a particular NF profile, with functional impairment correlating with BDNF levels and severity of washing symptoms correlating with NGF and GDNF levels. CI - Copyright (c) 2012 Elsevier Ireland Ltd. All rights reserved. FAU - Fontenelle, Leonardo F AU - Fontenelle LF AD - Anxiety and Depression Research Program, Institute of Psychiatry, Federal University of Rio de Janeiro & D'Or Institute for Research and Education, Av. Venceslau Bras 71 fundos, Botafogo, CEP 22290-140, Rio de Janeiro, Brazil. lfontenelle@gmail.com FAU - Barbosa, Izabela Guimaraes AU - Barbosa IG FAU - Luna, Juliano Victor AU - Luna JV FAU - Rocha, Natalia Pessoa AU - Rocha NP FAU - Silva Miranda, Aline AU - Silva Miranda A FAU - Teixeira, Antonio Lucio AU - Teixeira AL LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20120409 PL - Ireland TA - Psychiatry Res JT - Psychiatry research JID - 7911385 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (Glial Cell Line-Derived Neurotrophic Factor) RN - 9061-61-4 (Nerve Growth Factor) SB - IM MH - Adult MH - Anxiety/blood/diagnosis/psychology MH - Brain-Derived Neurotrophic Factor/*blood MH - Cross-Sectional Studies MH - Depression/blood/diagnosis/psychology MH - Female MH - Glial Cell Line-Derived Neurotrophic Factor/*blood MH - Humans MH - Male MH - Middle Aged MH - Nerve Growth Factor/*blood MH - Obsessive-Compulsive Disorder/*blood/psychology MH - Psychiatric Status Rating Scales EDAT- 2012/04/13 06:00 MHDA- 2013/05/07 06:00 CRDT- 2012/04/13 06:00 PHST- 2011/06/11 00:00 [received] PHST- 2012/01/25 00:00 [revised] PHST- 2012/03/17 00:00 [accepted] PHST- 2012/04/13 06:00 [entrez] PHST- 2012/04/13 06:00 [pubmed] PHST- 2013/05/07 06:00 [medline] AID - S0165-1781(12)00143-6 [pii] AID - 10.1016/j.psychres.2012.03.034 [doi] PST - ppublish SO - Psychiatry Res. 2012 Oct 30;199(3):195-200. doi: 10.1016/j.psychres.2012.03.034. Epub 2012 Apr 9.