PMID- 22496101
OWN - NLM
STAT- MEDLINE
DCOM- 20121015
LR  - 20131121
IS  - 1097-6817 (Electronic)
IS  - 0194-5998 (Linking)
VI  - 147
IP  - 2
DP  - 2012 Aug
TI  - The role of proton pump inhibitors in adenoid hypertrophy in children.
PG  - 329-34
LID - 10.1177/0194599812444528 [doi]
AB  - OBJECTIVES: To establish the efficacy of proton pump inhibitors (PPI) in the 
      treatment of adenoid hypertrophy in children. DESIGN: Randomized controlled 
      double-blinded clinical trial. POPULATION: Forty children, aged 2 to 12 years, 
      with adenoid hypertrophy fulfilling the inclusion and exclusion criteria. 
      METHODS: Patients were randomly allocated into 2 groups: one to be treated with 
      oral Losec MUPS for a period of 2 months (treatment group) and the other to be 
      given a low-dose vitamin C tablet for the same period (control group). The 
      patients were reviewed on 2 occasions during the 2-month study period, during 
      which endoscopy was performed to examine the adenoid glands to assess their size 
      and the larynx to assess signs of reflux disease. Examination of tonsillar size 
      was also performed. RESULTS: There was a significant reduction in adenoid size in 
      the treatment group, but the control group also demonstrated a significant 
      reduction in adenoid size. Comparison between the 2 groups in terms of adenoid 
      grade change between the first and second visits did not reveal any significant 
      statistical difference. CONCLUSION: The results of this study do not demonstrate 
      any efficacy of PPIs for adenoid hypertrophy in children, and these drugs should 
      not be used for this purpose.
FAU - Iqbal, Farim Rizal Wong
AU  - Iqbal FR
AD  - Department of Otorhinolaryngology, Faculty of Medicine, National University of 
      Malaysia, Bandar Tun Razak, Malaysia.
FAU - Goh, Bee See
AU  - Goh BS
FAU - Mazita, Ami
AU  - Mazita A
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20120411
PL  - England
TA  - Otolaryngol Head Neck Surg
JT  - Otolaryngology--head and neck surgery : official journal of American Academy of 
      Otolaryngology-Head and Neck Surgery
JID - 8508176
RN  - 0 (Proton Pump Inhibitors)
RN  - KG60484QX9 (Omeprazole)
SB  - IM
MH  - Adenoids/*pathology
MH  - Child
MH  - Child, Preschool
MH  - Double-Blind Method
MH  - Female
MH  - Humans
MH  - Hypertrophy/drug therapy
MH  - Male
MH  - Omeprazole/*therapeutic use
MH  - Prospective Studies
MH  - Proton Pump Inhibitors
EDAT- 2012/04/13 06:00
MHDA- 2012/10/16 06:00
CRDT- 2012/04/13 06:00
PHST- 2012/04/13 06:00 [entrez]
PHST- 2012/04/13 06:00 [pubmed]
PHST- 2012/10/16 06:00 [medline]
AID - 0194599812444528 [pii]
AID - 10.1177/0194599812444528 [doi]
PST - ppublish
SO  - Otolaryngol Head Neck Surg. 2012 Aug;147(2):329-34. doi: 
      10.1177/0194599812444528. Epub 2012 Apr 11.