PMID- 22496538
OWN - NLM
STAT- MEDLINE
DCOM- 20130110
LR  - 20220408
IS  - 1758-535X (Electronic)
IS  - 1079-5006 (Linking)
VI  - 67
IP  - 11
DP  - 2012 Nov
TI  - Effect of 12-week resistance exercise program on body composition, muscle 
      strength, physical function, and glucose metabolism in healthy, 
      insulin-resistant, and diabetic elderly Icelanders.
PG  - 1259-65
LID - 10.1093/gerona/gls096 [doi]
AB  - BACKGROUND: Insulin is a stimulator of skeletal muscle protein anabolism and 
      insulin resistance might therefore negatively affect muscle protein metabolism. 
      We investigated muscle mass and physical function before and after a resistance 
      exercise program in participants with prediabetes or type 2 diabetes mellitus 
      (T2DM) in comparison to healthy controls. METHODS: This was a secondary analysis 
      of a randomized controlled intervention designed to investigate resistance 
      training among older adults. Glucose metabolism status was not a selection 
      criteria for the trial, and group designation was done retrospectively. 
      Participants (N = 237, 73.7 +/- 5.7 y, 58.2% women) participated in a 12-week 
      resistance exercise program (3 times/week; three sets, six to eight repetitions 
      at 75%-80% of the one-repetition maximum), designed to increase strength and 
      muscle mass of major muscle groups. Body composition, muscular strength, timed up 
      and go test, 6-minute walk for distance, and blood chemical variables were 
      measured at baseline and endpoint. RESULTS: Participants completing the study (n 
      = 213) experienced significant changes in muscle strength or muscle function, 
      which did not differ significantly between healthy (n = 198), prediabetic (n = 
      20), and T2DM participants (n = 17). Changes in serum glucose during the 
      intervention differed by group: only glucose improved significantly in the 
      prediabetic group, glucose and triacylglycerol improved significantly in the 
      healthy group, whereas no serum parameter improved significantly in the T2DM 
      group. CONCLUSIONS: A 12-week resistance exercise program improves muscle 
      strength and muscle function to a similar extent in healthy, prediabetic, and 
      T2DM elderly people. However, according to our data, T2DM participants do not 
      experience favorable changes in fasting glucose or HbA(1C).
FAU - Geirsdottir, O G
AU  - Geirsdottir OG
AD  - Unit for Nutrition Research, Eiriksgata 29, Landspitali National University 
      Hospital, IS-101 Reykjavik, Iceland. olofgg@landspitali.is
FAU - Arnarson, A
AU  - Arnarson A
FAU - Briem, K
AU  - Briem K
FAU - Ramel, A
AU  - Ramel A
FAU - Jonsson, P V
AU  - Jonsson PV
FAU - Thorsdottir, I
AU  - Thorsdottir I
LA  - eng
SI  - ClinicalTrials.gov/NCT01074879
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20120410
PL  - United States
TA  - J Gerontol A Biol Sci Med Sci
JT  - The journals of gerontology. Series A, Biological sciences and medical sciences
JID - 9502837
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Body Composition
MH  - Diabetes Mellitus, Type 2/diagnosis/*therapy
MH  - Female
MH  - Follow-Up Studies
MH  - Glucose/*metabolism
MH  - Humans
MH  - Iceland
MH  - Insulin Resistance/physiology
MH  - Linear Models
MH  - Male
MH  - Muscle Strength/*physiology
MH  - Physical Fitness/physiology
MH  - Prediabetic State/diagnosis/*therapy
MH  - Program Evaluation
MH  - Reference Values
MH  - Resistance Training/*organization & administration
MH  - Risk Assessment
MH  - Statistics, Nonparametric
MH  - Time Factors
MH  - Treatment Outcome
EDAT- 2012/04/13 06:00
MHDA- 2013/01/11 06:00
CRDT- 2012/04/13 06:00
PHST- 2012/04/13 06:00 [entrez]
PHST- 2012/04/13 06:00 [pubmed]
PHST- 2013/01/11 06:00 [medline]
AID - gls096 [pii]
AID - 10.1093/gerona/gls096 [doi]
PST - ppublish
SO  - J Gerontol A Biol Sci Med Sci. 2012 Nov;67(11):1259-65. doi: 
      10.1093/gerona/gls096. Epub 2012 Apr 10.