PMID- 22497528
OWN - NLM
STAT- MEDLINE
DCOM- 20120815
LR  - 20220801
IS  - 1179-2000 (Electronic)
IS  - 1177-1062 (Linking)
VI  - 16
IP  - 2
DP  - 2012 Apr 1
TI  - Molecular diagnosis and management of viral infections in hematopoietic stem cell 
      transplant recipients.
PG  - 63-77
AB  - Viral infections after allogeneic hematopoietic stem cell transplantation (HSCT) 
      are important complications associated with high morbidity and mortality. In this 
      setting, reactivations of persisting latent viral pathogens from donor and/or 
      recipient cells play a central role whereas the sterile environment of transplant 
      units renders new infections less likely. The viruses currently regarded as most 
      relevant in the HSCT setting include particularly the herpes virus 
      family--specifically cytomegalovirus (CMV), Epstein-Barr virus (EBV), and human 
      herpesvirus 6 (HHV-6)--as well as human adenoviruses (AdVs) and the polyoma virus 
      BK (BKV). Timely detection and monitoring of virus copy numbers are prerequisites 
      for successful preemptive treatment approaches. Pre- and post-transplant 
      surveillance by sensitive and quantitative molecular methods has therefore become 
      an essential part of the diagnostic routine. In this review, we discuss 
      diagnostic aspects and the clinical management of the most important viral 
      infections in HSCT recipients, with a focus on pediatric patients.
FAU - Breuer, Sabine
AU  - Breuer S
AD  - Department of Pediatric Stem Cell Transplantation, St. Anna Childrens Hospital, 
      Medical University of Vienna, Vienna, Austria.
FAU - Rauch, Margit
AU  - Rauch M
FAU - Matthes-Martin, Susanne
AU  - Matthes-Martin S
FAU - Lion, Thomas
AU  - Lion T
LA  - eng
PT  - Journal Article
PT  - Review
PL  - New Zealand
TA  - Mol Diagn Ther
JT  - Molecular diagnosis & therapy
JID - 101264260
SB  - IM
MH  - Adenoviridae Infections/diagnosis/therapy
MH  - Cytomegalovirus Infections/diagnosis/therapy
MH  - Epstein-Barr Virus Infections/diagnosis/therapy
MH  - *Hematopoietic Stem Cell Transplantation/adverse effects
MH  - Herpes Simplex/diagnosis/therapy
MH  - Humans
MH  - Molecular Diagnostic Techniques
MH  - Polyomavirus Infections/diagnosis/therapy
MH  - Post-Exposure Prophylaxis
MH  - Reproducibility of Results
MH  - Roseolovirus Infections/diagnosis/therapy
MH  - Tumor Virus Infections/diagnosis/therapy
MH  - Virus Diseases/complications/*diagnosis/*drug therapy
EDAT- 2012/04/14 06:00
MHDA- 2012/08/16 06:00
CRDT- 2012/04/14 06:00
PHST- 2012/04/14 06:00 [entrez]
PHST- 2012/04/14 06:00 [pubmed]
PHST- 2012/08/16 06:00 [medline]
AID - 1 [pii]
AID - 10.1007/BF03256431 [doi]
PST - ppublish
SO  - Mol Diagn Ther. 2012 Apr 1;16(2):63-77. doi: 10.1007/BF03256431.