PMID- 22498326
OWN - NLM
STAT- MEDLINE
DCOM- 20120829
LR  - 20181201
IS  - 1876-7591 (Electronic)
IS  - 1876-7591 (Linking)
VI  - 5
IP  - 4
DP  - 2012 Apr
TI  - Prognostic value of late gadolinium enhancement in clinical outcomes for 
      hypertrophic cardiomyopathy.
PG  - 370-7
LID - 10.1016/j.jcmg.2011.11.021 [doi]
AB  - OBJECTIVES: The objective of this study was to perform a systematic review and 
      meta-analysis of the predictive value of late gadolinium enhancement (LGE) 
      cardiac magnetic resonance (CMR) for future cardiovascular events and death in 
      hypertrophic cardiomyopathy (HCM). BACKGROUND: The utility of LGE for detecting 
      myocardial fibrosis is well established. The prognostic value of LGE in HCM has 
      been described in several studies, but controversy exists given the limited power 
      of these studies to predict future events. METHODS: We searched multiple 
      databases including PubMed for studies of LGE in HCM that reported selected 
      clinical outcomes (cardiovascular mortality, sudden cardiac death [SCD], aborted 
      SCD, and heart failure death). We performed a systematic review of the literature 
      and meta-analysis to determine pooled odds ratios for these clinical events. 
      RESULTS: Four studies evaluated 1,063 patients over an average follow-up of 3.1 
      years. The pooled prevalence of LGE was 60%. The pooled odds ratios (OR) 
      demonstrate that LGE by CMR correlated with cardiac death (pooled OR: 2.92, 95% 
      confidence interval [CI]: 1.01 to 8.42; p = 0.047), heart failure death (pooled 
      OR: 5.68, 95% CI: 1.04 to 31.07; p = 0.045), and all-cause mortality (pooled OR: 
      4.46, 95% CI: 1.53 to 13.01; p = 0.006), and showed a trend toward significance 
      for predicting sudden death/aborted sudden death (pooled OR: 2.39, 95% CI: 0.87 
      to 6.58; p = 0.091). CONCLUSIONS: Late gadolinium enhancement by CMR has 
      prognostic value in predicting adverse cardiovascular events among HCM patients. 
      There are significant relationships between LGE and cardiovascular mortality, 
      heart failure death, and all-cause mortality in HCM. Additionally, LGE and 
      SCD/aborted SCD displayed a trend toward significance. The assessment of LGE by 
      CMR has the potential to provide important information to improve risk 
      stratification in HCM in clinical practice.
CI  - Copyright (c) 2012 American College of Cardiology Foundation. Published by Elsevier 
      Inc. All rights reserved.
FAU - Green, John J
AU  - Green JJ
AD  - Department of Medicine, Cardiology Division, University of Virginia, 
      Charlottesville, Virginia 22908, USA.
FAU - Berger, Jeffery S
AU  - Berger JS
FAU - Kramer, Christopher M
AU  - Kramer CM
FAU - Salerno, Michael
AU  - Salerno M
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
PL  - United States
TA  - JACC Cardiovasc Imaging
JT  - JACC. Cardiovascular imaging
JID - 101467978
RN  - 0 (Contrast Media)
RN  - AU0V1LM3JT (Gadolinium)
SB  - IM
CIN - JACC Cardiovasc Imaging. 2012 Jul;5(7):761-2; author reply 762-3. PMID: 22789948
MH  - Cardiomyopathy, Hypertrophic/*diagnosis/mortality
MH  - *Contrast Media
MH  - Death, Sudden, Cardiac/*epidemiology/etiology
MH  - Delayed Diagnosis
MH  - Fibrosis/diagnosis
MH  - *Gadolinium
MH  - Global Health
MH  - Humans
MH  - *Image Enhancement
MH  - Magnetic Resonance Imaging, Cine/*methods
MH  - Myocardium/*pathology
MH  - Prognosis
MH  - Risk Factors
MH  - Survival Rate/trends
EDAT- 2012/04/14 06:00
MHDA- 2012/08/30 06:00
CRDT- 2012/04/14 06:00
PHST- 2011/09/15 00:00 [received]
PHST- 2011/11/01 00:00 [revised]
PHST- 2011/11/08 00:00 [accepted]
PHST- 2012/04/14 06:00 [entrez]
PHST- 2012/04/14 06:00 [pubmed]
PHST- 2012/08/30 06:00 [medline]
AID - S1936-878X(12)00165-9 [pii]
AID - 10.1016/j.jcmg.2011.11.021 [doi]
PST - ppublish
SO  - JACC Cardiovasc Imaging. 2012 Apr;5(4):370-7. doi: 10.1016/j.jcmg.2011.11.021.