PMID- 22499875
OWN - NLM
STAT- MEDLINE
DCOM- 20120614
LR  - 20200314
IS  - 0032-5791 (Print)
IS  - 0032-5791 (Linking)
VI  - 91
IP  - 5
DP  - 2012 May
TI  - Maternal hyperthyroidism is associated with a decreased incidence of cold-induced 
      ascites in broiler chickens.
PG  - 1165-72
LID - 10.3382/ps.2011-02021 [doi]
AB  - A hypothesis was tested that providing the breeder hens with exogenous thyroxine 
      (T(4)) would help their offspring to better survive the ascites-inducing 
      condition during the growing period. In total, 132 broiler breeder hens were 
      randomly assigned to one of 3 treatments: control (CON), hypothyroid [HYPO; 
      6-N-propyl-2-thiouracil (PTU)-treated], and hyperthyroid (HYPER; T(4)-treated). 
      The hens were artificially inseminated, and the hatching eggs (n = 1,320) were 
      incubated. No eggs in the HYPO group hatched. The 1-d-old male chicks (n = 288) 
      from other groups were reared for 42 d under standard or low ambient temperature 
      to induce ascites. Blood samples were drawn from the hens, embryos, and broilers 
      for determination of T(4) and triiodothyronine (T(3)). The hematocrit was also 
      determined in broilers. The PTU-treated hens had an increased BW along with lower 
      plasma T(3) and T(4) concentrations. Plasma T(4) was higher in the HYPER hens 
      compared with CON hens, but T(3) concentration was not different between these 
      groups. The fertility rate was not affected by either hypo- or hyperthyroidism. 
      The embryos in the HYPO group had lower plasma T(3) and T(4) concentrations at d 
      18 of embryonic development and internal pipping. Higher plasma T(4) was recorded 
      in the HYPER birds at internal pipping, although plasma T(3) concentration was 
      not affected at this stage. Maternal hyperthyroidism decreased the overall 
      incidence of ascites in the cold-exposed chickens (10.0 vs. 33.4% for HYPER and 
      CON groups, respectively). Although the effect of maternal PTU or T(4) treatment 
      on plasma thyroid hormones and on the right ventricle-to-total ventricular weight 
      ratio in the broilers was not significant, the cold-exposed healthy CON chicks 
      showed higher hematocrit values, compared with the HYPER birds. It was concluded 
      that maternal hyperthyroidism could decrease the incidence of cold-induced 
      ascites in broiler chickens; however, probable causal mechanisms remain to be 
      elucidated.
FAU - Akhlaghi, A
AU  - Akhlaghi A
AD  - Department of Animal Science, Shiraz University, Shiraz, Iran. 
      aakhlaghi@shirazu.ac.ir
FAU - Zamiri, M J
AU  - Zamiri MJ
FAU - Zare Shahneh, A
AU  - Zare Shahneh A
FAU - Jafari Ahangari, Y
AU  - Jafari Ahangari Y
FAU - Nejati Javaremi, A
AU  - Nejati Javaremi A
FAU - Rahimi Mianji, G
AU  - Rahimi Mianji G
FAU - Mollasalehi, M R
AU  - Mollasalehi MR
FAU - Shojaie, H
AU  - Shojaie H
FAU - Akhlaghi, A A
AU  - Akhlaghi AA
FAU - Deldar, H
AU  - Deldar H
FAU - Atashi, H
AU  - Atashi H
FAU - Ansari Pirsaraei, Z
AU  - Ansari Pirsaraei Z
FAU - Zhandi, M
AU  - Zhandi M
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - England
TA  - Poult Sci
JT  - Poultry science
JID - 0401150
RN  - 721M9407IY (Propylthiouracil)
RN  - Q51BO43MG4 (Thyroxine)
SB  - IM
MH  - Animals
MH  - Ascites/etiology/*veterinary
MH  - *Chickens
MH  - Cold Temperature/*adverse effects
MH  - Female
MH  - Hyperthyroidism/chemically induced/*veterinary
MH  - Hypothyroidism/chemically induced/veterinary
MH  - Male
MH  - Poultry Diseases/chemically induced/*prevention & control
MH  - Propylthiouracil/adverse effects
MH  - Thyroxine/adverse effects
MH  - Weight Gain/drug effects
EDAT- 2012/04/14 06:00
MHDA- 2012/06/15 06:00
CRDT- 2012/04/14 06:00
PHST- 2012/04/14 06:00 [entrez]
PHST- 2012/04/14 06:00 [pubmed]
PHST- 2012/06/15 06:00 [medline]
AID - S0032-5791(19)39603-8 [pii]
AID - 10.3382/ps.2011-02021 [doi]
PST - ppublish
SO  - Poult Sci. 2012 May;91(5):1165-72. doi: 10.3382/ps.2011-02021.