PMID- 22500797
OWN - NLM
STAT- MEDLINE
DCOM- 20120608
LR  - 20231120
IS  - 1097-4172 (Electronic)
IS  - 0092-8674 (Print)
IS  - 0092-8674 (Linking)
VI  - 149
IP  - 2
DP  - 2012 Apr 13
TI  - mTOR signaling in growth control and disease.
PG  - 274-93
LID - 10.1016/j.cell.2012.03.017 [doi]
AB  - The mechanistic target of rapamycin (mTOR) signaling pathway senses and 
      integrates a variety of environmental cues to regulate organismal growth and 
      homeostasis. The pathway regulates many major cellular processes and is 
      implicated in an increasing number of pathological conditions, including cancer, 
      obesity, type 2 diabetes, and neurodegeneration. Here, we review recent advances 
      in our understanding of the mTOR pathway and its role in health, disease, and 
      aging. We further discuss pharmacological approaches to treat human pathologies 
      linked to mTOR deregulation.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Laplante, Mathieu
AU  - Laplante M
AD  - Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 
      02142, USA.
FAU - Sabatini, David M
AU  - Sabatini DM
LA  - eng
GR  - R01 CA103866/CA/NCI NIH HHS/United States
GR  - R01 CA103866-09/CA/NCI NIH HHS/United States
GR  - CAPMC/CIHR/Canada
GR  - HHMI/Howard Hughes Medical Institute/United States
GR  - R37 AI047389/AI/NIAID NIH HHS/United States
GR  - R01 CA129105-05/CA/NCI NIH HHS/United States
GR  - R37 AI047389-13/AI/NIAID NIH HHS/United States
GR  - R01 CA129105/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Review
PL  - United States
TA  - Cell
JT  - Cell
JID - 0413066
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Animals
MH  - Humans
MH  - Metabolic Diseases/metabolism
MH  - Neoplasms/metabolism
MH  - Neurodegenerative Diseases/metabolism
MH  - *Signal Transduction
MH  - Stem Cells/metabolism
MH  - TOR Serine-Threonine Kinases/*metabolism
PMC - PMC3331679
MID - NIHMS369262
EDAT- 2012/04/17 06:00
MHDA- 2012/06/09 06:00
PMCR- 2013/04/13
CRDT- 2012/04/17 06:00
PHST- 2011/11/29 00:00 [received]
PHST- 2012/04/17 06:00 [entrez]
PHST- 2012/04/17 06:00 [pubmed]
PHST- 2012/06/09 06:00 [medline]
PHST- 2013/04/13 00:00 [pmc-release]
AID - S0092-8674(12)00351-0 [pii]
AID - 10.1016/j.cell.2012.03.017 [doi]
PST - ppublish
SO  - Cell. 2012 Apr 13;149(2):274-93. doi: 10.1016/j.cell.2012.03.017.