PMID- 22502622
OWN - NLM
STAT- MEDLINE
DCOM- 20120529
LR  - 20151119
IS  - 1089-5159 (Print)
IS  - 1089-5159 (Linking)
VI  - 17
IP  - 1
DP  - 2012 Mar
TI  - Nutritional supplement therapy improves oxidative stress, immune response, 
      pulmonary function, and quality of life in allergic asthma patients: an 
      open-label pilot study.
PG  - 42-56
AB  - OBJECTIVE: To examine the effects of nutritional supplement therapy on 
      oxidant-antioxidant status, inflammation and immune system responses, pulmonary 
      function, and health-related quality of life in patients with mild to moderate 
      allergic asthma. METHODS: Adult asthma patients (n=30) received daily multiple 
      nutrient supplements for two months. Age- and gender-matched healthy controls 
      (n=30) did not receive any supplements. Enzymatic and non-enzymatic antioxidant 
      status, malondialdehyde (MDA), high-sensitivity C-reactive protein (hs-CRP), 
      immunoglobulin E (IgE) and T-lymphocyte subsets, pulmonary function indices, as 
      well as scores for asthma control and quality of life, were assessed at baseline, 
      at one month of treatment, and at two months of treatment, which was also the end 
      of the study. RESULTS: At baseline, asthma patients had significantly higher IgE, 
      MDA, copper (Cu), hs-CRP, and CD19 and CD4/CD8 lymphocyte ratios, and decreased 
      selenium (Se), zinc (Zn), beta-carotene, vitamins C and E, and catalase, glutathione 
      peroxidase (GPx) and glutathione reductase (GR) activities compared to healthy 
      controls (p < 0.05). During the study period, asthmatics showed non-significantly 
      increased pulmonary function and a trend toward lower IgE levels, markedly 
      reduced MDA, Cu, hs-CRP, and CD19 and CD4/CD8 ratios, and increases in levels of 
      Se, Zn, beta-carotene, vitamins C and E, and enzymatic antioxidant activities. Also, 
      their asthma control and health-related quality-of-life scores increased 
      significantly by the end of the study. CONCLUSION: Our results indicate that 
      nutritional supplement therapy may improve dysregulated oxidant and antioxidant 
      status, inflammation and immune responses, pulmonary function, and health-related 
      quality of life in patients with mild to moderate allergic asthma.
FAU - Guo, Chih-Hung
AU  - Guo CH
AD  - Institute of Biomedical Nutrition, Hung Kuang University, Taiwan, Republic of 
      China.
FAU - Liu, Po-Jen
AU  - Liu PJ
FAU - Lin, Kuan-Pin
AU  - Lin KP
FAU - Chen, Pei-Chung
AU  - Chen PC
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Altern Med Rev
JT  - Alternative medicine review : a journal of clinical therapeutic
JID - 9705340
RN  - 0 (Biomarkers)
RN  - 0 (Trace Elements)
RN  - 0 (Vitamins)
RN  - 11103-57-4 (Vitamin A)
RN  - 1406-18-4 (Vitamin E)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 789U1901C5 (Copper)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - H6241UJ22B (Selenium)
MH  - Adult
MH  - Asthma/*drug therapy
MH  - Biomarkers/metabolism
MH  - C-Reactive Protein/metabolism
MH  - Copper/metabolism
MH  - *Dietary Supplements
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/metabolism
MH  - Male
MH  - Oxidative Stress/*drug effects
MH  - Pilot Projects
MH  - *Quality of Life
MH  - Respiratory Function Tests
MH  - Selenium/administration & dosage
MH  - T-Lymphocyte Subsets/metabolism
MH  - Trace Elements
MH  - Treatment Outcome
MH  - Vitamin A/administration & dosage
MH  - Vitamin E/administration & dosage
MH  - Vitamins/*administration & dosage/metabolism
EDAT- 2012/04/17 06:00
MHDA- 2012/05/30 06:00
CRDT- 2012/04/17 06:00
PHST- 2012/04/17 06:00 [entrez]
PHST- 2012/04/17 06:00 [pubmed]
PHST- 2012/05/30 06:00 [medline]
PST - ppublish
SO  - Altern Med Rev. 2012 Mar;17(1):42-56.