PMID- 22502644
OWN - NLM
STAT- MEDLINE
DCOM- 20130416
LR  - 20220129
IS  - 1365-2052 (Electronic)
IS  - 0268-9146 (Linking)
VI  - 43
IP  - 6
DP  - 2012 Dec
TI  - Detection of quantitative trait loci for resistance to gastrointestinal nematode 
      infections in Creole goats.
PG  - 768-75
LID - 10.1111/j.1365-2052.2012.02341.x [doi]
AB  - This study aimed to identify regions of the genome affecting resistance to 
      gastrointestinal nematodes in a Creole goat population naturally exposed to a 
      mixed nematode infection (Haemonchus contortus, Trichostrongylus colubriformis 
      and Oesophagostomum columbianum) by grazing on irrigated pasture. A genome-wide 
      quantitative trait loci (QTL) scan was performed on 383 offspring from 12 
      half-sib families. A total of 101 microsatellite markers were genotyped. Traits 
      analysed were faecal egg count (FEC), packed cell volume (PCV), eosinophil count 
      and bodyweight (BW) at 7 and 11 months of age. Levels of activity of 
      immunoglobulin A (IgA) and activity of immunoglobulin E (IgE) anti-Haemonchus 
      contortus L3 crude extracts and adult excretion/secretion products (ESPs) were 
      also analysed. Using interval mapping, this study identified 13 QTL for parasite 
      resistance. Two QTL linked with FEC were found on chromosomes 22 and 26. Three 
      QTL were detected on chromosomes 7, 8 and 14 for eosinophil counts. Three QTL 
      linked with PCV were identified on chromosomes 5, 9 and 21. A QTL for BW at 7 
      months of age was found on chromosome 6. Lastly, two QTL detected on chromosomes 
      3 and 10 were associated with IgE anti-L3, and IgE anti-ESP was linked with two 
      QTL on chromosomes 1 and 26. This study is the first to have identified regions 
      of the genome linked with nematode resistance in a goat population using a genome 
      scan. These results provide useful tools for the understanding of parasite 
      resistance in small ruminants.
CI  - (c) 2012 The Authors, Animal Genetics (c) 2012 Stichting International Foundation for 
      Animal Genetics.
FAU - de la Chevrotiere, C
AU  - de la Chevrotiere C
AD  - INRA, UR143, Unite de Recherches Zootechniques, Domaine Duclos, 97170 
      Petit-Bourg, France.
FAU - Bishop, S C
AU  - Bishop SC
FAU - Arquet, R
AU  - Arquet R
FAU - Bambou, J C
AU  - Bambou JC
FAU - Schibler, L
AU  - Schibler L
FAU - Amigues, Y
AU  - Amigues Y
FAU - Moreno, C
AU  - Moreno C
FAU - Mandonnet, N
AU  - Mandonnet N
LA  - eng
GR  - BBS/E/D/20211552/BB_/Biotechnology and Biological Sciences Research 
      Council/United Kingdom
GR  - BBS/E/D/20211554/BB_/Biotechnology and Biological Sciences Research 
      Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120415
PL  - England
TA  - Anim Genet
JT  - Animal genetics
JID - 8605704
SB  - IM
MH  - Animals
MH  - Chromosomes, Mammalian/genetics
MH  - Disease Resistance/*genetics
MH  - Female
MH  - Gastrointestinal Tract/parasitology
MH  - Genotype
MH  - Goat Diseases/genetics/*immunology
MH  - Goats/genetics
MH  - Haemonchiasis/immunology/parasitology/veterinary
MH  - Haemonchus/immunology
MH  - Male
MH  - Microsatellite Repeats
MH  - Nematode Infections/genetics/immunology/*veterinary
MH  - Oesophagostomiasis/immunology/parasitology/veterinary
MH  - Oesophagostomum/immunology
MH  - *Quantitative Trait Loci
MH  - Trichostrongylosis/immunology/parasitology/veterinary
MH  - Trichostrongylus/immunology
EDAT- 2012/04/17 06:00
MHDA- 2013/04/17 06:00
CRDT- 2012/04/17 06:00
PHST- 2011/11/27 00:00 [accepted]
PHST- 2012/04/17 06:00 [entrez]
PHST- 2012/04/17 06:00 [pubmed]
PHST- 2013/04/17 06:00 [medline]
AID - 10.1111/j.1365-2052.2012.02341.x [doi]
PST - ppublish
SO  - Anim Genet. 2012 Dec;43(6):768-75. doi: 10.1111/j.1365-2052.2012.02341.x. Epub 
      2012 Apr 15.