PMID- 22503396
OWN - NLM
STAT- MEDLINE
DCOM- 20121102
LR  - 20120828
IS  - 1879-0852 (Electronic)
IS  - 0959-8049 (Linking)
VI  - 48
IP  - 14
DP  - 2012 Sep
TI  - Risk factors to predict the incidence of surgical adverse events following open 
      or laparoscopic surgery for apparent early stage endometrial cancer: results from 
      a randomised controlled trial.
PG  - 2155-62
LID - 10.1016/j.ejca.2012.03.013 [doi]
AB  - AIMS: To identify risk factors for major adverse events (AEs) and to develop a 
      nomogram to predict the probability of such AEs in patients who have surgery for 
      apparent early stage endometrial cancer. METHODS: We used data from 753 patients 
      who were randomised to either total laparoscopic hysterectomy or total abdominal 
      hysterectomy in the LACE trial. Serious adverse events that prolonged hospital 
      stay or postoperative adverse events (using common terminology criteria 3+, CTCAE 
      V3) were considered major AEs. We analysed pre-surgical characteristics that were 
      associated with the risk of developing major AEs by multivariate logistic 
      regression. We identified a parsimonious model by backward stepwise logistic 
      regression. The six most significant or clinically important variables were 
      included in the nomogram to predict the risk of major AEs within 6weeks of 
      surgery and the nomogram was internally validated. RESULTS: Overall, 132 (17.5%) 
      patients had at least one major AE. An open surgical approach (laparotomy), 
      higher Charlson's medical co-morbidities score, moderately differentiated tumours 
      on curettings, higher baseline Eastern Cooperative Oncology Group (ECOG) score, 
      higher body mass index and low haemoglobin levels were associated with AE and 
      were used in the nomogram. The bootstrap corrected concordance index of the 
      nomogram was 0.63 and it showed good calibration. CONCLUSIONS: Six pre-surgical 
      factors independently predicted the risk of major AEs. This research might form 
      the basis to develop risk reduction strategies to minimise the risk of AEs among 
      patients undergoing surgery for apparent early stage endometrial cancer.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Kondalsamy-Chennakesavan, Srinivas
AU  - Kondalsamy-Chennakesavan S
AD  - University of Queensland, School of Medicine, QLD, Australia.
FAU - Janda, Monika
AU  - Janda M
FAU - Gebski, Val
AU  - Gebski V
FAU - Baker, Jannah
AU  - Baker J
FAU - Brand, Alison
AU  - Brand A
FAU - Hogg, Russell
AU  - Hogg R
FAU - Jobling, Thomas W
AU  - Jobling TW
FAU - Land, Russell
AU  - Land R
FAU - Manolitsas, Tom
AU  - Manolitsas T
FAU - Nascimento, Marcelo
AU  - Nascimento M
FAU - Neesham, Deborah
AU  - Neesham D
FAU - Nicklin, James L
AU  - Nicklin JL
FAU - Oehler, Martin K
AU  - Oehler MK
FAU - Otton, Geoff
AU  - Otton G
FAU - Perrin, Lewis
AU  - Perrin L
FAU - Salfinger, Stuart
AU  - Salfinger S
FAU - Hammond, Ian
AU  - Hammond I
FAU - Leung, Yee
AU  - Leung Y
FAU - Sykes, Peter
AU  - Sykes P
FAU - Ngan, Hextan
AU  - Ngan H
FAU - Garrett, Andrea
AU  - Garrett A
FAU - Laney, Michael
AU  - Laney M
FAU - Ng, Tong Yow
AU  - Ng TY
FAU - Tam, Karfai
AU  - Tam K
FAU - Chan, Karen
AU  - Chan K
FAU - Wrede, David H
AU  - Wrede DH
FAU - Pather, Selvan
AU  - Pather S
FAU - Simcock, Bryony
AU  - Simcock B
FAU - Farrell, Rhonda
AU  - Farrell R
FAU - Robertson, Gregory
AU  - Robertson G
FAU - Walker, Graeme
AU  - Walker G
FAU - McCartney, Anthony
AU  - McCartney A
FAU - Obermair, Andreas
AU  - Obermair A
LA  - eng
SI  - ClinicalTrials.gov/NCT00096408
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20120412
PL  - England
TA  - Eur J Cancer
JT  - European journal of cancer (Oxford, England : 1990)
JID - 9005373
SB  - IM
MH  - Algorithms
MH  - Australia/epidemiology
MH  - Decision Support Techniques
MH  - Endometrial Neoplasms/epidemiology/pathology/*surgery
MH  - Female
MH  - Humans
MH  - Hysterectomy/*adverse effects/methods
MH  - Incidence
MH  - Laparoscopy/*adverse effects
MH  - Length of Stay
MH  - Logistic Models
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Neoplasm Staging
MH  - Nomograms
MH  - Odds Ratio
MH  - Postoperative Complications/*epidemiology/therapy
MH  - Reproducibility of Results
MH  - Risk Assessment
MH  - Risk Factors
MH  - Time Factors
MH  - Treatment Outcome
EDAT- 2012/04/17 06:00
MHDA- 2012/11/03 06:00
CRDT- 2012/04/17 06:00
PHST- 2011/12/19 00:00 [received]
PHST- 2012/03/12 00:00 [revised]
PHST- 2012/03/12 00:00 [accepted]
PHST- 2012/04/17 06:00 [entrez]
PHST- 2012/04/17 06:00 [pubmed]
PHST- 2012/11/03 06:00 [medline]
AID - S0959-8049(12)00276-6 [pii]
AID - 10.1016/j.ejca.2012.03.013 [doi]
PST - ppublish
SO  - Eur J Cancer. 2012 Sep;48(14):2155-62. doi: 10.1016/j.ejca.2012.03.013. Epub 2012 
      Apr 12.