PMID- 22503660
OWN - NLM
STAT- MEDLINE
DCOM- 20130206
LR  - 20120926
IS  - 1873-0183 (Electronic)
IS  - 1568-9972 (Linking)
VI  - 11
IP  - 12
DP  - 2012 Oct
TI  - Distinct roles of myeloid and plasmacytoid dendritic cells in systemic lupus 
      erythematosus.
PG  - 890-7
LID - S1568-9972(12)00064-X [pii]
LID - 10.1016/j.autrev.2012.03.004 [doi]
AB  - Dendritic cells (DCs) constitute a heterogeneous population of professional 
      antigen presenting cells which are the initiators and key regulators for both 
      immunity and tolerance induction. The significance and impact of DC biology in 
      contemporary immunology and medical research is heightened by the award of the 
      2011 Nobel Prize for Medicine and Physiology to Ralf Steinman for his discovery 
      and subsequent work on the role of DC in adaptive immunity. As a central 
      regulator of immune responses, DCs also play a pivotal role in the pathogenesis 
      of chronic inflammatory autoimmune conditions such as systemic lupus 
      erythematosus (SLE). In this review, we will focus on the respective role of the 
      two major subsets of blood DC, namely myeloid (m)-DC and plasmacytoid (p)-DC, in 
      SLE immunopathogenesis. Accumulating evidence has highlighted pDCs as the culprit 
      for SLE pathogenesis, mainly through type-I interferon production. Latest 
      findings in the field also decipher the mechanisms by which pDCs interact with 
      neutrophils and platelets and contribute to SLE development. The recent surge of 
      interest in studying microRNA regulation in SLE pathogenesis will also be 
      discussed.
CI  - Copyright (c) 2012 Elsevier B.V. All rights reserved.
FAU - Chan, Vera Sau-Fong
AU  - Chan VS
AD  - Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong 
      Kong, Pokfulam, Hong Kong.
FAU - Nie, Yin-Jie
AU  - Nie YJ
FAU - Shen, Nan
AU  - Shen N
FAU - Yan, Sheng
AU  - Yan S
FAU - Mok, Mo-Yin
AU  - Mok MY
FAU - Lau, Chak-Sing
AU  - Lau CS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20120320
PL  - Netherlands
TA  - Autoimmun Rev
JT  - Autoimmunity reviews
JID - 101128967
RN  - 0 (Interferon Type I)
RN  - 0 (MicroRNAs)
SB  - IM
MH  - Animals
MH  - Antigen Presentation
MH  - Blood Platelets/immunology
MH  - Cell Communication
MH  - Dendritic Cells/*immunology
MH  - Humans
MH  - Interferon Type I/*immunology
MH  - Lupus Erythematosus, Systemic/genetics/*immunology
MH  - MicroRNAs/genetics
MH  - Myeloid Cells/*immunology
MH  - Neutrophils/immunology
EDAT- 2012/04/17 06:00
MHDA- 2013/02/07 06:00
CRDT- 2012/04/17 06:00
PHST- 2012/03/01 00:00 [received]
PHST- 2012/03/11 00:00 [accepted]
PHST- 2012/04/17 06:00 [entrez]
PHST- 2012/04/17 06:00 [pubmed]
PHST- 2013/02/07 06:00 [medline]
AID - S1568-9972(12)00064-X [pii]
AID - 10.1016/j.autrev.2012.03.004 [doi]
PST - ppublish
SO  - Autoimmun Rev. 2012 Oct;11(12):890-7. doi: 10.1016/j.autrev.2012.03.004. Epub 
      2012 Mar 20.