PMID- 22504067
OWN - NLM
STAT- MEDLINE
DCOM- 20120628
LR  - 20181201
IS  - 1090-2430 (Electronic)
IS  - 0014-4886 (Linking)
VI  - 235
IP  - 2
DP  - 2012 Jun
TI  - Neuregulin-1/ErbB4 signaling controls the migration of oligodendrocyte precursor 
      cells during development.
PG  - 610-20
LID - 10.1016/j.expneurol.2012.03.015 [doi]
AB  - During embryonic development, the oligodendrocyte precursors (OPCs) are generated 
      in specific oligodendrogliogenic sites within the neural tube and migrate to 
      colonize the entire CNS. Different factors have been shown to influence the OPC 
      migration and differentiation, including morphogens, growth factors, chemotropic 
      molecules, and extracellular matrix proteins. Neuregulins have been shown to 
      influence the migration of neuronal precursors as well as the movement and 
      differentiation of Schwann cells for peripheral myelination, but their role in 
      the motility of OPCs has not been explored. In the present study, we have used 
      the optic nerve as an experimental model to examine the function of Nrg1 and its 
      ErbB4 receptor in the migration of OPCs in the developing embryo. In vitro 
      experiments revealed that Nrg1 is a potent chemoattractant for the first wave of 
      OPCs, and that this effect is mediated via ErbB4 receptor. In contrast, OPCs 
      colonizing the optic nerve at postnatal stages (PDGFRalpha(+)-OPCs) does not respond 
      to Nrg1-chemoattraction. We also found that mouse embryos lacking ErbB4 display 
      deficits in early OPC migration away from different oligodendrogliogenic regions 
      in vivo. The present findings reveal a new role for Nrg1/ErbB4 signaling in 
      regulating OPC migration selectively during early stages of CNS development.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Ortega, M Cristina
AU  - Ortega MC
AD  - Grupo de Neurobiologia del Desarrollo-GNDe, Hospital Nacional de Paraplejicos, 
      Toledo, Spain.
FAU - Bribian, Ana
AU  - Bribian A
FAU - Peregrin, Sandra
AU  - Peregrin S
FAU - Gil, M Trinidad
AU  - Gil MT
FAU - Marin, Oscar
AU  - Marin O
FAU - de Castro, Fernando
AU  - de Castro F
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120402
PL  - United States
TA  - Exp Neurol
JT  - Experimental neurology
JID - 0370712
RN  - 0 (Neuregulin-1)
RN  - 0 (Nrg1 protein, mouse)
RN  - EC 2.7.10.1 (ERBB4 protein, human)
RN  - EC 2.7.10.1 (ErbB Receptors)
RN  - EC 2.7.10.1 (Erbb4 protein, mouse)
RN  - EC 2.7.10.1 (Receptor, ErbB-4)
SB  - IM
MH  - Animals
MH  - COS Cells
MH  - Cell Differentiation/physiology
MH  - Cell Movement/*physiology
MH  - Cells, Cultured
MH  - Cricetinae
MH  - Cricetulus
MH  - Embryonic Development/physiology
MH  - ErbB Receptors/*physiology
MH  - Humans
MH  - Mice
MH  - Mice, Knockout
MH  - Mice, Transgenic
MH  - Neural Stem Cells/*physiology
MH  - Neuregulin-1/*physiology
MH  - Oligodendroglia/*physiology
MH  - Optic Nerve/cytology/embryology/physiology
MH  - Receptor, ErbB-4
MH  - Signal Transduction/*physiology
EDAT- 2012/04/17 06:00
MHDA- 2012/06/29 06:00
CRDT- 2012/04/17 06:00
PHST- 2011/08/30 00:00 [received]
PHST- 2012/03/20 00:00 [revised]
PHST- 2012/03/25 00:00 [accepted]
PHST- 2012/04/17 06:00 [entrez]
PHST- 2012/04/17 06:00 [pubmed]
PHST- 2012/06/29 06:00 [medline]
AID - S0014-4886(12)00113-6 [pii]
AID - 10.1016/j.expneurol.2012.03.015 [doi]
PST - ppublish
SO  - Exp Neurol. 2012 Jun;235(2):610-20. doi: 10.1016/j.expneurol.2012.03.015. Epub 
      2012 Apr 2.