PMID- 22504954
OWN - NLM
STAT- MEDLINE
DCOM- 20121101
LR  - 20211021
IS  - 2042-0226 (Electronic)
IS  - 1672-7681 (Print)
IS  - 1672-7681 (Linking)
VI  - 9
IP  - 4
DP  - 2012 Jul
TI  - Regulation of TH17 cell differentiation by innate immune signals.
PG  - 287-95
LID - 10.1038/cmi.2012.10 [doi]
AB  - Upon antigen stimulation, naive T helper cells differentiate into distinct 
      lineages to attain specialized properties and effector functions. T(H)17 cells, a 
      recently identified lineage of CD4(+) effector T cells, play a key role in the 
      immune defense against fungi and extracellular bacteria, but also contribute to 
      the pathogenesis of many autoimmune conditions. The differentiation of T(H)17 
      cells is orchestrated by an intricate network of signaling pathways and 
      transcriptional regulators in T cells. While the involvement of T cell-intrinsic 
      pathways has been described extensively, we are just beginning to appreciate how 
      T(H)17 cell development is shaped by extrinsic pathways, especially the innate 
      immune signals. Dendritic cells (DCs), the most important cell type to bridge 
      innate and adaptive immunity, drive T(H)17 cell differentiation by providing 
      antigenic, costimulatory and cytokine signals. This is mediated by the 
      recognition of innate and inflammatory signals by DCs via pattern recognition 
      receptors, cytokine receptors and other immunomodulatory receptors that in turn 
      activate the intracellular signaling network. In particular, p38alpha MAP kinase has 
      emerged as a critical pathway to program DC-dependent T(H)17 cell differentiation 
      by integrating multiple instructive signals in DCs. Here, we summarize the 
      current knowledge on the mechanisms by which DC-derived innate immune signals 
      drive T(H)17 cell differentiation.
FAU - Huang, Gonghua
AU  - Huang G
AD  - Department of Immunology, St Jude Children's Research Hospital, Memphis, TN 
      38105, USA.
FAU - Wang, Yanyan
AU  - Wang Y
FAU - Chi, Hongbo
AU  - Chi H
LA  - eng
GR  - K01 AR053573/AR/NIAMS NIH HHS/United States
GR  - R01 NS064599/NS/NINDS NIH HHS/United States
GR  - R21 AI094089/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20120416
PL  - China
TA  - Cell Mol Immunol
JT  - Cellular & molecular immunology
JID - 101242872
RN  - 0 (Cytokines)
RN  - 0 (Receptors, Pattern Recognition)
RN  - EC 2.7.11.24 (p38 Mitogen-Activated Protein Kinases)
SB  - IM
MH  - Animals
MH  - Cell Differentiation/immunology
MH  - Cytokines/*immunology
MH  - Dendritic Cells/*immunology
MH  - Humans
MH  - *Immunity, Innate
MH  - Receptor Cross-Talk/immunology
MH  - Receptors, Pattern Recognition/*immunology
MH  - Signal Transduction/immunology
MH  - Th17 Cells/*immunology
MH  - p38 Mitogen-Activated Protein Kinases/*immunology
PMC - PMC3423893
MID - NIHMS396480
EDAT- 2012/04/17 06:00
MHDA- 2012/11/02 06:00
PMCR- 2012/07/01
CRDT- 2012/04/17 06:00
PHST- 2012/04/17 06:00 [entrez]
PHST- 2012/04/17 06:00 [pubmed]
PHST- 2012/11/02 06:00 [medline]
PHST- 2012/07/01 00:00 [pmc-release]
AID - cmi201210 [pii]
AID - 10.1038/cmi.2012.10 [doi]
PST - ppublish
SO  - Cell Mol Immunol. 2012 Jul;9(4):287-95. doi: 10.1038/cmi.2012.10. Epub 2012 Apr 
      16.