PMID- 22505233
OWN - NLM
STAT- MEDLINE
DCOM- 20130206
LR  - 20190221
IS  - 1724-6008 (Electronic)
IS  - 0393-6155 (Linking)
VI  - 27
IP  - 2
DP  - 2012 Jul 19
TI  - Role of monocyte chemoattractant protein-1, tumor necrosis factor-alpha and 
      interleukin-6 in the control of malignant pleural effusion and survival in 
      patients with primary lung adenocarcinoma.
PG  - e118-24
LID - 10.5301/JBM.2012.9197 [doi]
AB  - This study aimed at assessing the role of monocyte chemoattractant protein-1 
      (MCP-1), tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) in the 
      control of pleural effusion (PE) and survival in patients with primary lung 
      adenocarcinoma. The concentrations of the 3 cytokines were measured in PE from 79 
      lung adenocarcinoma patients with malignant pleural effusion (MPE) and 23 
      patients with tuberculosis. Data were correlated with the efficacy of MPE control 
      and patient survival. The level of MCP-1 in PE was significantly higher in 
      patients with lung adenocarcinoma than those with tuberculosis. By contrast, the 
      levels of TNF-alpha and IL-6 were significantly lower in patients with lung 
      adenocarcinoma than those with tuberculosis. An MCP-1 level greater than 3,187 
      pg/mL (which was used as a cutoff point) indicated failure to control MPE (odds 
      ratio [OR]=2.82, 95% confidence interval [CI]=1.02-7.82, p=0.04). In multivariate 
      analysis, MCP-1 was confirmed as an independent prognostic factor for 
      progression-free survival (hazard ratio [HR]=2.02, 95% CI=1.24-3.30, p=0.01). The 
      level of MCP-1 in PE appears to be a reliable surrogate marker for evaluating the 
      therapeutic efficacy in the control of MPE and predicting survival in lung 
      adenocarcinoma patients with MPE.
FAU - Qian, Qian
AU  - Qian Q
AD  - First Department of Respiratory Medicine, Nanjing Chest Hospital, Nanjing - 
      China.
FAU - Sun, Wen-Kui
AU  - Sun WK
FAU - Zhan, Ping
AU  - Zhan P
FAU - Zhang, Yu
AU  - Zhang Y
FAU - Song, Yong
AU  - Song Y
FAU - Yu, Li-Ke
AU  - Yu LK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120719
PL  - United States
TA  - Int J Biol Markers
JT  - The International journal of biological markers
JID - 8712411
RN  - 0 (Interleukin-6)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adenocarcinoma/*metabolism/pathology
MH  - Adenocarcinoma of Lung
MH  - Aged
MH  - Disease-Free Survival
MH  - Female
MH  - Humans
MH  - Interleukin-6/*metabolism
MH  - Kaplan-Meier Estimate
MH  - Lung Neoplasms/*metabolism/pathology
MH  - Male
MH  - Middle Aged
MH  - Pleural Effusion, Malignant/*metabolism/pathology
MH  - Survival Analysis
MH  - Tumor Necrosis Factor-alpha/*metabolism
EDAT- 2012/04/17 06:00
MHDA- 2013/02/07 06:00
CRDT- 2012/04/17 06:00
PHST- 2012/01/05 00:00 [accepted]
PHST- 2012/04/17 06:00 [entrez]
PHST- 2012/04/17 06:00 [pubmed]
PHST- 2013/02/07 06:00 [medline]
AID - 28966F2E-7F56-48D5-925F-D78992880911 [pii]
AID - 10.5301/JBM.2012.9197 [doi]
PST - epublish
SO  - Int J Biol Markers. 2012 Jul 19;27(2):e118-24. doi: 10.5301/JBM.2012.9197.