PMID- 22507324
OWN - NLM
STAT- MEDLINE
DCOM- 20120531
LR  - 20170214
IS  - 0394-6320 (Print)
IS  - 0394-6320 (Linking)
VI  - 25
IP  - 1
DP  - 2012 Jan-Mar
TI  - Neurotrophins, their receptors and KI-67 in human GH-secreting pituitary 
      adenomas: an immunohistochemical analysis.
PG  - 117-25
AB  - Pituitary adenomas are a diverse group of tumors arising from the pituitary 
      gland. Typically, they are small, slow-growing, hormonally inactive lesions that 
      come to light as incidental findings on radiologic or postmortem examinations, 
      although some small, slow-growing lesions with excessive hormonal activity may 
      manifest with a clinical syndrome. The family of neurotrophins plays a key role 
      in the development and maintenance of the pituitary endocrine cell function and 
      in the regulation of hypothalamo-pituitary-adrenocortical axis activity. The 
      objective of our experimental study is to investigate the localization of the 
      neurotrophins, their relative receptors and to detect the expression level of 
      Ki-67 to determine whether all these factors participate in the transformation 
      and development of human pituitary adenomas. A very strong expression of 
      Neurotrophin-3 (NT-3) and its receptor TrKC was observed in the extracellular 
      matrix (ECM) and vessel endothelium, together with a clear/marked presence of 
      Brain-derived neurotrophic factor (BDNF), and its receptor TrKB, thus confirming 
      their direct involvement in the progression of pituitary adenomas. On the 
      contrary, NGF (Nerve growth factor) and its receptor TrKA and p75NTR were weakly 
      expressed in the epithelial gland cells and the ECM.
FAU - Artico, M
AU  - Artico M
AD  - Department of Sensory Organs, Sapienza University of Rome, Rome, Italy. 
      marco.artico@uniroma1.it
FAU - Bianchi, E
AU  - Bianchi E
FAU - Magliulo, G
AU  - Magliulo G
FAU - De Vincentiis, M
AU  - De Vincentiis M
FAU - De Santis, E
AU  - De Santis E
FAU - Orlandi, A
AU  - Orlandi A
FAU - Santoro, A
AU  - Santoro A
FAU - Pastore, F S
AU  - Pastore FS
FAU - Giangaspero, F
AU  - Giangaspero F
FAU - Caruso, R
AU  - Caruso R
FAU - Re, M
AU  - Re M
FAU - Fumagalli, L
AU  - Fumagalli L
LA  - eng
PT  - Journal Article
PL  - England
TA  - Int J Immunopathol Pharmacol
JT  - International journal of immunopathology and pharmacology
JID - 8911335
RN  - 0 (Ki-67 Antigen)
RN  - 0 (NGFR protein, human)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Receptors, Nerve Growth Factor)
RN  - EC 2.7.10.1 (Receptor, trkA)
RN  - EC 2.7.10.1 (Receptor, trkB)
RN  - EC 2.7.10.1 (Receptor, trkC)
SB  - IM
MH  - Adenoma/*chemistry
MH  - Extracellular Matrix/chemistry
MH  - Growth Hormone-Secreting Pituitary Adenoma/*chemistry
MH  - Humans
MH  - Immunohistochemistry
MH  - Ki-67 Antigen/*analysis
MH  - Nerve Growth Factors/*analysis
MH  - Nerve Tissue Proteins/analysis
MH  - Receptor, trkA/analysis
MH  - Receptor, trkB/analysis
MH  - Receptor, trkC/analysis
MH  - Receptors, Nerve Growth Factor/analysis
EDAT- 2012/04/18 06:00
MHDA- 2012/06/01 06:00
CRDT- 2012/04/18 06:00
PHST- 2012/04/18 06:00 [entrez]
PHST- 2012/04/18 06:00 [pubmed]
PHST- 2012/06/01 06:00 [medline]
AID - 14 [pii]
AID - 10.1177/039463201202500114 [doi]
PST - ppublish
SO  - Int J Immunopathol Pharmacol. 2012 Jan-Mar;25(1):117-25. doi: 
      10.1177/039463201202500114.