PMID- 22508170
OWN - NLM
STAT- MEDLINE
DCOM- 20121119
LR  - 20220419
IS  - 1423-0372 (Electronic)
IS  - 1011-6125 (Linking)
VI  - 90
IP  - 3
DP  - 2012
TI  - Bilateral cingulotomy and anterior capsulotomy applied to patients with 
      aggressiveness.
PG  - 151-60
LID - 10.1159/000336746 [doi]
AB  - OBJECTIVE: To perform a preliminary study on the effects and safety of bilateral 
      cingulotomy and anterior capsulotomy in patients with aggressive behavior. 
      PATIENTS AND METHODS: Twenty-three psychiatric patients showing aggressive 
      behavior refractory to conventional treatment were initially evaluated. The 
      subjects were clinically selected using the Overt Aggression Scale (OAS) and the 
      Global Assessment of Functioning Scale (GAF). Each case was carefully reviewed by 
      the Ethics Committee of Mexico's General Hospital. Once selection criteria were 
      met, stereotactic lesions were made using radiofrequency on the anterior limb of 
      the internal capsule and supragenual cingulum. Statistical differences were 
      evaluated with a Wilcoxon test at 6 months and at 4 years. RESULTS: Ten patients 
      underwent surgery. Their OAS and GAF scores decreased after the procedure at the 
      6-month (p < 0.05) and at the 4-year (p = 0.068) follow-up. Four patients showed 
      mild and transitory postsurgical complications (hyperphagia and somnolence). 
      CONCLUSIONS: Bilateral anterior capsulotomy in combination with cingulotomy may 
      reduce aggressive behavior and improve clinical evaluations. Very strict clinical 
      and ethical evaluations were applied prior to considering patients for this 
      treatment.
CI  - Copyright (c) 2012 S. Karger AG, Basel.
FAU - Jimenez, Fiacro
AU  - Jimenez F
AD  - Functional Neurosurgery, Stereotactic and Radiosurgery Unit, Anahuac University, 
      Mexico City, Mexico. fiacroj@yahoo.com
FAU - Soto, Julian E
AU  - Soto JE
FAU - Velasco, Francisco
AU  - Velasco F
FAU - Andrade, Pablo
AU  - Andrade P
FAU - Bustamante, Juan J
AU  - Bustamante JJ
FAU - Gomez, Paulina
AU  - Gomez P
FAU - Ramirez, Ylian
AU  - Ramirez Y
FAU - Carrillo-Ruiz, Jose D
AU  - Carrillo-Ruiz JD
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20120411
PL  - Switzerland
TA  - Stereotact Funct Neurosurg
JT  - Stereotactic and functional neurosurgery
JID - 8902881
SB  - IM
CIN - Stereotact Funct Neurosurg. 2013;91(3):198-200. PMID: 23446292
CIN - Stereotact Funct Neurosurg. 2013;91(3):201-3. PMID: 23446321
MH  - Adolescent
MH  - Adult
MH  - *Aggression
MH  - Female
MH  - Gyrus Cinguli/*surgery
MH  - Humans
MH  - Internal Capsule/*surgery
MH  - Male
MH  - Middle Aged
MH  - Psychosurgery/*methods
MH  - Stereotaxic Techniques
MH  - Treatment Outcome
EDAT- 2012/04/18 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/04/18 06:00
PHST- 2010/07/07 00:00 [received]
PHST- 2011/05/04 00:00 [accepted]
PHST- 2012/04/18 06:00 [entrez]
PHST- 2012/04/18 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 000336746 [pii]
AID - 10.1159/000336746 [doi]
PST - ppublish
SO  - Stereotact Funct Neurosurg. 2012;90(3):151-60. doi: 10.1159/000336746. Epub 2012 
      Apr 11.