PMID- 22508771
OWN - NLM
STAT- MEDLINE
DCOM- 20120927
LR  - 20220330
IS  - 1538-3652 (Electronic)
IS  - 0003-987X (Linking)
VI  - 148
IP  - 7
DP  - 2012 Jul
TI  - Ocular adverse effects of systemic treatment with isotretinoin.
PG  - 803-8
LID - 10.1001/archdermatol.2012.352 [doi]
AB  - OBJECTIVE: To examine whether isotretinoin therapy could result in deleterious 
      ocular effects, as previously described in case report studies. DESIGN: 
      Retrospective cohort study. SETTING: The study was conducted using the electronic 
      medical databases of a large health maintenance organization in Israel. PATIENTS: 
      The study population consisted of 14 682 adolescents and young adults who were 
      new users of isotretinoin for acne and 2 age- and sex-matched comparison groups 
      (isotretinoin-naive patients with acne and acne-free patients). MAIN OUTCOME 
      MEASURES: Ocular adverse effects (AEs) or purchases of ophthalmic medications 
      within 1 year after the first dispensed isotretinoin prescription. RESULTS: In 
      total, 13.8% of the isotretinoin group experienced ocular AEs vs 9.6% of the 
      isotretinoin-naive group and 7.1% of the acne-free group. During a 1-year 
      follow-up period, the isotretinoin group had significantly higher risk for any 
      ocular AEs (hazard ratio, 1.70; P.001) compared with the acne-free group. No such 
      increased risk was observed for the isotretinoin-naive group. The isotretinoin 
      group had higher relative risks for inflammatory and structural AEs. CONCLUSION: 
      Isotretinoin use may be associated with short-term ocular events, especially 
      conjunctivitis, underscoring the importance of educating patients and caregivers 
      about these potentially important AEs of the therapy.
FAU - Neudorfer, Meira
AU  - Neudorfer M
AD  - Department of Ophthalmology, Tel Aviv Medical Center, Tel Aviv, Israel.
FAU - Goldshtein, Inbal
AU  - Goldshtein I
FAU - Shamai-Lubovitz, Orna
AU  - Shamai-Lubovitz O
FAU - Chodick, Gabriel
AU  - Chodick G
FAU - Dadon, Yuval
AU  - Dadon Y
FAU - Shalev, Varda
AU  - Shalev V
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Arch Dermatol
JT  - Archives of dermatology
JID - 0372433
RN  - 0 (Dermatologic Agents)
RN  - EH28UP18IF (Isotretinoin)
SB  - IM
MH  - Acne Vulgaris/*drug therapy
MH  - Adolescent
MH  - Case-Control Studies
MH  - Cohort Studies
MH  - Conjunctivitis/chemically induced/epidemiology
MH  - Databases, Factual
MH  - Dermatologic Agents/*adverse effects/therapeutic use
MH  - Eye Diseases/*chemically induced/epidemiology
MH  - Follow-Up Studies
MH  - Health Maintenance Organizations
MH  - Humans
MH  - Isotretinoin/*adverse effects/therapeutic use
MH  - Israel/epidemiology
MH  - Male
MH  - Patient Education as Topic/methods
MH  - Proportional Hazards Models
MH  - Retrospective Studies
MH  - Risk
MH  - Young Adult
EDAT- 2012/04/18 06:00
MHDA- 2012/09/28 06:00
CRDT- 2012/04/18 06:00
PHST- 2012/04/18 06:00 [entrez]
PHST- 2012/04/18 06:00 [pubmed]
PHST- 2012/09/28 06:00 [medline]
AID - archdermatol.2012.352 [pii]
AID - 10.1001/archdermatol.2012.352 [doi]
PST - ppublish
SO  - Arch Dermatol. 2012 Jul;148(7):803-8. doi: 10.1001/archdermatol.2012.352.