PMID- 22509108
OWN - NLM
STAT- MEDLINE
DCOM- 20120709
LR  - 20221207
IS  - 1090-0535 (Electronic)
IS  - 1090-0535 (Linking)
VI  - 18
DP  - 2012
TI  - Polymorphism in the TNF-alpha(-863) locus associated with reduced risk of primary 
      open angle glaucoma.
PG  - 779-85
AB  - PURPOSE: Tumor necrosis factor-alpha (TNF-alpha), an important proinflammatory cytokine, 
      exerts a variety of physiologic and pathogenic effects that lead to tissue 
      destruction. Recent laboratory evidence indicates that TNF-alpha have either 
      protective or adverse effects on primary open angle glaucoma (POAG). Inheritance 
      of the TNF-alpha (-863) C allele has been associated with an elevated risk of 
      Alzheimer disease. The neuronal injuries associated with Alzheimer disease have 
      several similarities with the optic nerve changes often seen with POAG. In this 
      study we investigated the possible association between the TNF-alpha (-863) 
      polymorphism and the development of POAG. METHODS: A total of 234 patients with 
      POAG were recruited and compared with 230 healthy controls in a Chinese 
      population. Sequence-specific primers with 3' end mismatches were used to 
      identify the presence of specific allelic variants by polymerase chain reaction 
      (PCR) amplification. Patients and controls were genotyped for the A/C 
      polymorphism at position -863 of the TNF-alpha gene promoter region. RESULTS: The 
      frequency of the TNF-alpha (-863)A allele (22% versus 30%, respectively; p=0.007) and 
      the carriers of the TNF-alpha (-863)A allele (37% versus 48%; p=0.017, OR 0.63, 95% 
      CI 0.44-0.92) were lower in POAG patients compared with those in controls. There 
      is a reduced risk of POAG associated with homozygosity for the TNF-alpha (-863)A 
      allele (AA genotype) compared with that in the control population (AA genotype; 
      7% versus 11%, respectively, p=0.037; OR 0.5, 95% CI 0.26-0.98). CONCLUSIONS: The 
      TNF-alpha (-863)A allele polymorphism may be a protective factor in the development 
      of POAG.
FAU - Wang, Chun-Yuan
AU  - Wang CY
AD  - Department of Ophthalmology, Taichung Veterans General Hospital, National 
      Yang-Ming University, Taichung, Taiwan, Republic of China. cywangtw@yahoo.com
FAU - Shen, Ying-Cheng
AU  - Shen YC
FAU - Wei, Li-Chen
AU  - Wei LC
FAU - Lin, Keng-Hung
AU  - Lin KH
FAU - Feng, Shih-Chao
AU  - Feng SC
FAU - Yang, Yi-Yin
AU  - Yang YY
FAU - Chiu, Chun-Hung
AU  - Chiu CH
FAU - Tsai, Hin-Yeung
AU  - Tsai HY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120331
PL  - United States
TA  - Mol Vis
JT  - Molecular vision
JID - 9605351
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - Asian People/*genetics
MH  - Case-Control Studies
MH  - Female
MH  - Gene Frequency
MH  - Glaucoma, Open-Angle/*genetics
MH  - Homozygote
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Phenotype
MH  - Polymerase Chain Reaction
MH  - *Polymorphism, Single Nucleotide
MH  - Promoter Regions, Genetic
MH  - Risk
MH  - Taiwan
MH  - Tumor Necrosis Factor-alpha/*genetics
PMC - PMC3324355
EDAT- 2012/04/18 06:00
MHDA- 2012/07/10 06:00
PMCR- 2012/01/01
CRDT- 2012/04/18 06:00
PHST- 2012/01/05 00:00 [received]
PHST- 2012/03/26 00:00 [accepted]
PHST- 2012/04/18 06:00 [entrez]
PHST- 2012/04/18 06:00 [pubmed]
PHST- 2012/07/10 06:00 [medline]
PHST- 2012/01/01 00:00 [pmc-release]
AID - 83 [pii]
AID - 2012MOLVIS0010 [pii]
PST - ppublish
SO  - Mol Vis. 2012;18:779-85. Epub 2012 Mar 31.