PMID- 22510149
OWN - NLM
STAT- MEDLINE
DCOM- 20120910
LR  - 20220331
IS  - 1600-0609 (Electronic)
IS  - 0902-4441 (Linking)
VI  - 89
IP  - 1
DP  - 2012 Jul
TI  - Double-hit BCL2/MYC translocations in a consecutive cohort of patients with large 
      B-cell lymphoma - a single centre's experience.
PG  - 63-71
LID - 10.1111/j.1600-0609.2012.01787.x [doi]
AB  - Concurrent BCL2 and MYC translocations, so called double hit (DH), are a rare 
      finding in large B-cell lymphoma (LBCL). Based on data from retrospective series, 
      DH has been correlated with aggressive clinical behaviour and poor outcome. We 
      conducted a consecutive study of DH incidence and correlation with pathologic and 
      clinical characteristics, including response to Rituximab-containing chemotherapy 
      and survival, in an unselected cohort of patients with LBCL. Translocations 
      involving BCL2 and MYC loci were examined with fluorescent in situ hybridization 
      (FISH) in 157 patients with diffuse large B-cell lymphoma (DLBCL) or B-cell 
      lymphoma, unclassifiable, with features intermediate between diffuse large B-cell 
      lymphoma and Burkitt lymphoma (BCLU). The incidence of DH was 11% in the total 
      cohort, 7% of primary LBCL and 21% of transformed LBCL. DH lymphomas were all GCB 
      immunophenotype and were more often BCLU. No clinical characteristics were 
      correlated with the presence of DH, which also had no impact on overall response 
      rate (ORR), relapse rate or overall survival (OS). However, sub-stratification of 
      DH lymphomas by FISH indicated a possible inferior survival related to 
      immunoglobulin MYC translocation partner gene. Screening of patients with BCLU 
      and DLBCL of GCB type for DH BCL2/MYC translocation including MYC translocation 
      partner gene may provide important prognostic information.
CI  - (c) 2012 John Wiley & Sons A/S.
FAU - Pedersen, Mette O
AU  - Pedersen MO
AD  - Department of Pathology, Herlev Hospital, Herlev, Denmark.
FAU - Gang, Anne O
AU  - Gang AO
FAU - Poulsen, Tim S
AU  - Poulsen TS
FAU - Knudsen, Helle
AU  - Knudsen H
FAU - Lauritzen, Anne F
AU  - Lauritzen AF
FAU - Nielsen, Signe L
AU  - Nielsen SL
FAU - Gang, Uffe O
AU  - Gang UO
FAU - Norgaard, Peter
AU  - Norgaard P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120426
PL  - England
TA  - Eur J Haematol
JT  - European journal of haematology
JID - 8703985
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Cohort Studies
MH  - Female
MH  - *Genes, bcl-2
MH  - *Genes, myc
MH  - Humans
MH  - Lymphoma, Large B-Cell, Diffuse/diagnosis/*genetics/mortality/therapy
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Prognosis
MH  - *Translocation, Genetic
MH  - Treatment Outcome
EDAT- 2012/04/19 06:00
MHDA- 2012/09/11 06:00
CRDT- 2012/04/19 06:00
PHST- 2012/03/25 00:00 [accepted]
PHST- 2012/04/19 06:00 [entrez]
PHST- 2012/04/19 06:00 [pubmed]
PHST- 2012/09/11 06:00 [medline]
AID - 10.1111/j.1600-0609.2012.01787.x [doi]
PST - ppublish
SO  - Eur J Haematol. 2012 Jul;89(1):63-71. doi: 10.1111/j.1600-0609.2012.01787.x. Epub 
      2012 Apr 26.