PMID- 22510423
OWN - NLM
STAT- MEDLINE
DCOM- 20121005
LR  - 20181201
IS  - 1879-0844 (Electronic)
IS  - 1388-9842 (Linking)
VI  - 14
IP  - 6
DP  - 2012 Jun
TI  - Meta-analysis of randomized controlled trials evaluating left ventricular vs. 
      biventricular pacing in heart failure: effect on all-cause mortality and 
      hospitalizations.
PG  - 652-60
LID - 10.1093/eurjhf/hfs040 [doi]
AB  - AIM: Randomized controlled trials (RCTs) showed that biventricular (BiV) pacing 
      reduces heart failure (HF) hospitalizations and mortality in patients with New 
      York Heart Association (NYHA) class III-IV HF, left ventricular (LV) dysfunction, 
      and wide QRS. We performed a systematic review and meta-analysis of the RCTs 
      comparing LV-only vs. biventricular (BiV) pacing in candidates for cardiac 
      resynchronization therapy (CRT). METHODS AND RESULTS: The systematic review 
      selected five RCTs (out of 1888 analysed reports) with a cumulative number of 372 
      patients randomized to BiV pacing and 258 to LV-only pacing. The meta-analysis 
      shows that BiV pacing is not superior to LV-only pacing and that these two pacing 
      modalities do not differ with regard to death or heart transplantation [LV-only 
      vs. BiV pacing odds ratio (OR) 1.24, 95% confidence interval (CI) 0.57-2.70 with 
      the fixed effect model, OR 1.25, 95% CI 0.48-3.24 with the random effect model]. 
      Specific data on hospitalizations were available only in two RCTs with a 
      cumulative number of 127 patients randomized to BiV and 123 to LV-only pacing. 
      The meta-analysis shows that BiV pacing is not superior to LV-only pacing and 
      that these two pacing modalities do not differ with regard to this outcome 
      (LV-only vs. BiV pacing OR 0.86, 95% CI 0.49-1.50 with the fixed effect model, OR 
      0.86, 95% CI 0.49-1.50 with the random effect model). CONCLUSIONS: Biventricular 
      pacing is not superior to LV-only pacing, and these two pacing modalities appear 
      to achieve similar efficacy in candidates for CRT for moderate to severe HF, in 
      terms of all-cause mortality and hospitalizations during follow-up.
FAU - Boriani, Giuseppe
AU  - Boriani G
AD  - Institute of Cardiology, University of Bologna, Bologna, Italy. 
      giuseppe.boriani@unibo.it
FAU - Gardini, Beatrice
AU  - Gardini B
FAU - Diemberger, Igor
AU  - Diemberger I
FAU - Bacchi Reggiani, Maria Letizia
AU  - Bacchi Reggiani ML
FAU - Biffi, Mauro
AU  - Biffi M
FAU - Martignani, Cristian
AU  - Martignani C
FAU - Ziacchi, Matteo
AU  - Ziacchi M
FAU - Valzania, Cinzia
AU  - Valzania C
FAU - Gasparini, Maurizio
AU  - Gasparini M
FAU - Padeletti, Luigi
AU  - Padeletti L
FAU - Branzi, Angelo
AU  - Branzi A
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PT  - Systematic Review
DEP - 20120417
PL  - England
TA  - Eur J Heart Fail
JT  - European journal of heart failure
JID - 100887595
SB  - IM
MH  - *Cardiac Resynchronization Therapy
MH  - Chi-Square Distribution
MH  - Confidence Intervals
MH  - Heart Failure/mortality/*therapy
MH  - *Hospitalization
MH  - Humans
MH  - Odds Ratio
MH  - Prognosis
MH  - Randomized Controlled Trials as Topic/*methods
MH  - *Stroke Volume
MH  - Treatment Outcome
MH  - *Ventricular Function, Left
EDAT- 2012/04/19 06:00
MHDA- 2012/10/06 06:00
CRDT- 2012/04/19 06:00
PHST- 2012/04/19 06:00 [entrez]
PHST- 2012/04/19 06:00 [pubmed]
PHST- 2012/10/06 06:00 [medline]
AID - hfs040 [pii]
AID - 10.1093/eurjhf/hfs040 [doi]
PST - ppublish
SO  - Eur J Heart Fail. 2012 Jun;14(6):652-60. doi: 10.1093/eurjhf/hfs040. Epub 2012 
      Apr 17.