PMID- 22510429
OWN - NLM
STAT- MEDLINE
DCOM- 20121113
LR  - 20211021
IS  - 1474-9726 (Electronic)
IS  - 1474-9718 (Print)
IS  - 1474-9718 (Linking)
VI  - 11
IP  - 4
DP  - 2012 Aug
TI  - Caloric restriction may reverse age-related autonomic decline in humans.
PG  - 644-50
LID - 10.1111/j.1474-9726.2012.00825.x [doi]
AB  - Caloric restriction (CR) retards aging in laboratory rodents. No information is 
      available on the effects of long-term CR on physiologic markers of aging and 
      longevity in humans. Heart rate variability (HRV) is a marker for cardiac 
      autonomic functioning. The progressive decline in HRV with aging and the 
      association of higher HRV with better health outcomes are well established. Heart 
      rate variability assessment is a reliable tool by which the effects of CR on 
      autonomic function can be assessed. Time- and frequency-domain analyses compared 
      24-h HRV in 22 CR individuals aged 35-82 years and 20 age-matched controls eating 
      Western diets (WD). The CR group was significantly leaner than the WD group. 
      Heart rate was significantly lower, and virtually, all HRV values were 
      significantly higher in the CR group than in the WD group (P < 0.002). Heart rate 
      variability in the CR individuals was comparable with published norms for healthy 
      individuals 20 years younger. In addition, when differences in heart rate (HR) 
      and HRV between CR and WD were compared with previously published changes in HRV 
      induced in healthy adults given atenolol, percent differences in each measure 
      were generally similar in direction and magnitude and suggested declines in 
      sympathetic and increases in parasympathetic modulation of HR and increased 
      circadian variability associated with CR. These findings provide evidence that CR 
      has direct systemic effects that counter the expected age-associated changes in 
      autonomic function so that HRV indexes in CR individuals are similar to those of 
      individuals 20 years younger eating WDs.
CI  - (c) 2012 The Authors. Aging Cell (c) 2012 Blackwell Publishing Ltd/Anatomical Society 
      of Great Britain and Ireland.
FAU - Stein, Phyllis K
AU  - Stein PK
AD  - HRV Laboratory, Washington University School of Medicine, St. Louis, MO 63110, 
      USA. pstein@dom.wustl.edu
FAU - Soare, Andreea
AU  - Soare A
FAU - Meyer, Timothy E
AU  - Meyer TE
FAU - Cangemi, Roberto
AU  - Cangemi R
FAU - Holloszy, John O
AU  - Holloszy JO
FAU - Fontana, Luigi
AU  - Fontana L
LA  - eng
GR  - P30 DK056341/DK/NIDDK NIH HHS/United States
GR  - UL1 RR024992/RR/NCRR NIH HHS/United States
GR  - UL1 TR000448/TR/NCATS NIH HHS/United States
GR  - P30DK056341/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20120521
PL  - England
TA  - Aging Cell
JT  - Aging cell
JID - 101130839
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Aging/*physiology
MH  - Analysis of Variance
MH  - Autonomic Nervous System/*physiology
MH  - *Caloric Restriction
MH  - Case-Control Studies
MH  - Female
MH  - Heart Rate/physiology
MH  - Humans
MH  - Longevity/physiology
MH  - Male
MH  - Middle Aged
MH  - Risk Factors
PMC - PMC3598611
MID - NIHMS373745
EDAT- 2012/04/19 06:00
MHDA- 2012/11/14 06:00
PMCR- 2013/08/01
CRDT- 2012/04/19 06:00
PHST- 2012/04/19 06:00 [entrez]
PHST- 2012/04/19 06:00 [pubmed]
PHST- 2012/11/14 06:00 [medline]
PHST- 2013/08/01 00:00 [pmc-release]
AID - 10.1111/j.1474-9726.2012.00825.x [doi]
PST - ppublish
SO  - Aging Cell. 2012 Aug;11(4):644-50. doi: 10.1111/j.1474-9726.2012.00825.x. Epub 
      2012 May 21.