PMID- 22510533
OWN - NLM
STAT- MEDLINE
DCOM- 20130930
LR  - 20211021
IS  - 1460-2199 (Electronic)
IS  - 1047-3211 (Print)
IS  - 1047-3211 (Linking)
VI  - 23
IP  - 5
DP  - 2013 May
TI  - NMDA-dependent switch of proBDNF actions on developing GABAergic synapses.
PG  - 1085-96
LID - 10.1093/cercor/bhs071 [doi]
AB  - The brain-derived neurotrophic factor (BDNF) has emerged as an important 
      messenger for activity-dependent development of neuronal network. Recent findings 
      have suggested that a significant proportion of BDNF can be secreted as a 
      precursor (proBDNF) and cleaved by extracellular proteases to yield the mature 
      form. While the actions of proBDNF on maturation and plasticity of excitatory 
      synapses have been studied, the effect of the precursor on developing GABAergic 
      synapses remains largely unknown. Here, we show that regulated secretion of 
      proBDNF exerts a bidirectional control of GABAergic synaptic activity with NMDA 
      receptors driving the polarity of the plasticity. When NMDA receptors are 
      activated during ongoing synaptic activity, regulated Ca(2+)-dependent secretion 
      of proBDNF signals via p75(NTR) to depress GABAergic synaptic activity, while in 
      the absence of NMDA receptors activation, secreted proBDNF induces a 
      p75(NTR)-dependent potentiation of GABAergic synaptic activity. These results 
      revealed a new function for proBDNF-p75(NTR) signaling in synaptic plasticity and 
      a novel mechanism by which synaptic activity can modulate the development of 
      GABAergic synaptic connections.
FAU - Langlois, Anais
AU  - Langlois A
AD  - Institut National de la Sante et de la Recherche Medicale Unite 901, Marseille 
      13009, France.
FAU - Diabira, Diabe
AU  - Diabira D
FAU - Ferrand, Nadine
AU  - Ferrand N
FAU - Porcher, Christophe
AU  - Porcher C
FAU - Gaiarsa, Jean-Luc
AU  - Gaiarsa JL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120417
PL  - United States
TA  - Cereb Cortex
JT  - Cerebral cortex (New York, N.Y. : 1991)
JID - 9110718
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 6384-92-5 (N-Methylaspartate)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Cell Enlargement
MH  - Cell Proliferation
MH  - GABAergic Neurons/*physiology
MH  - Hippocampus/*physiology
MH  - N-Methylaspartate/*metabolism
MH  - Neuronal Plasticity/*physiology
MH  - Rats
MH  - Rats, Wistar
MH  - Synapses/*physiology
MH  - Synaptic Transmission/*physiology
PMC - PMC3615346
EDAT- 2012/04/19 06:00
MHDA- 2013/10/01 06:00
PMCR- 2014/05/01
CRDT- 2012/04/19 06:00
PHST- 2012/04/19 06:00 [entrez]
PHST- 2012/04/19 06:00 [pubmed]
PHST- 2013/10/01 06:00 [medline]
PHST- 2014/05/01 00:00 [pmc-release]
AID - bhs071 [pii]
AID - 10.1093/cercor/bhs071 [doi]
PST - ppublish
SO  - Cereb Cortex. 2013 May;23(5):1085-96. doi: 10.1093/cercor/bhs071. Epub 2012 Apr 
      17.