PMID- 22514016
OWN - NLM
STAT- MEDLINE
DCOM- 20130116
LR  - 20220408
IS  - 1097-0045 (Electronic)
IS  - 0270-4137 (Linking)
VI  - 72
IP  - 16
DP  - 2012 Dec 1
TI  - A high-fat diet enhances proliferation of prostate cancer cells and activates 
      MCP-1/CCR2 signaling.
PG  - 1779-88
LID - 10.1002/pros.22531 [doi]
AB  - BACKGROUND: Dietary patterns including high-fat diet (HFD) and high-carbohydrate 
      diet (HCD) play an important role in prostate cancer progression. However, which 
      of these diets have the greatest effect on tumor progression and its underlying 
      mechanisms remains unclear. METHODS: We investigated the effects of different 
      diets on prostate cancer cell growth and the relevant circulating factors 
      including serum insulin, growth factors, and inflammatory cytokines using the in 
      vivo and ex vivo model. RESULTS: The tumor growth of prostate cancer LNCaP 
      xenograft was significantly higher in the HFD group than in the HCD and control 
      diet (CD) groups (P = 0.01; HFD vs. HCD, P = 0.025; HFD vs. CD, P = 0.003). The 
      mean level of the serum monocyte chemoattractant protein-1 (MCP-1) in the HFD 
      group was significantly higher than that in the HCD and CD groups (P = 0.024; HFD 
      vs. HCD, P = 0.033; HFD vs. CD, P = 0.001). The mRNA levels of CC chemokine 
      receptor 2 (CCR2), which is an MCP-1 receptor, and the expression of activated 
      Akt were the highest in the HFD group. Furthermore, serum from HFD-fed mice 
      enhanced the proliferation of two PCa cells and CCR2 knockdown inhibited 
      HFD-induced proliferation of LNCaP cells. CONCLUSIONS: An HFD enhanced prostate 
      cancer cell growth more strongly than an HCD or CD. MCP-1/CCR2 signaling may be 
      involved in an HFD-induced prostate cancer progression.
CI  - Copyright (c) 2012 Wiley Periodicals, Inc.
FAU - Huang, Mingguo
AU  - Huang M
AD  - Department of Urology, Akita University Graduate School of Medicine, Akita, 
      Japan.
FAU - Narita, Shintaro
AU  - Narita S
FAU - Numakura, Kazuyuki
AU  - Numakura K
FAU - Tsuruta, Hiroshi
AU  - Tsuruta H
FAU - Saito, Mitsuru
AU  - Saito M
FAU - Inoue, Takamitsu
AU  - Inoue T
FAU - Horikawa, Yohei
AU  - Horikawa Y
FAU - Tsuchiya, Norihiko
AU  - Tsuchiya N
FAU - Habuchi, Tomonori
AU  - Habuchi T
LA  - eng
PT  - Journal Article
DEP - 20120418
PL  - United States
TA  - Prostate
JT  - The Prostate
JID - 8101368
RN  - 0 (Ccl2 protein, mouse)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Cytokines)
RN  - 0 (Insulin)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
SB  - IM
MH  - Animals
MH  - Cell Line, Tumor
MH  - *Cell Proliferation
MH  - Chemokine CCL2/*metabolism
MH  - Cytokines/blood
MH  - *Diet, High-Fat
MH  - Disease Progression
MH  - Humans
MH  - Insulin/blood
MH  - Insulin-Like Growth Factor I/metabolism
MH  - Male
MH  - Mice
MH  - Neoplasm Transplantation
MH  - Prostate/metabolism/pathology
MH  - Prostatic Neoplasms/blood/metabolism/*pathology
MH  - Signal Transduction/*physiology
EDAT- 2012/04/20 06:00
MHDA- 2013/01/17 06:00
CRDT- 2012/04/20 06:00
PHST- 2012/02/07 00:00 [received]
PHST- 2012/03/30 00:00 [accepted]
PHST- 2012/04/20 06:00 [entrez]
PHST- 2012/04/20 06:00 [pubmed]
PHST- 2013/01/17 06:00 [medline]
AID - 10.1002/pros.22531 [doi]
PST - ppublish
SO  - Prostate. 2012 Dec 1;72(16):1779-88. doi: 10.1002/pros.22531. Epub 2012 Apr 18.