PMID- 22514254
OWN - NLM
STAT- MEDLINE
DCOM- 20121029
LR  - 20211021
IS  - 1569-9285 (Electronic)
IS  - 1569-9293 (Print)
IS  - 1569-9285 (Linking)
VI  - 15
IP  - 1
DP  - 2012 Jul
TI  - Late gadolinium enhancement as a potential marker of increased perioperative risk 
      in aortic valve replacement.
PG  - 45-50
LID - 10.1093/icvts/ivs098 [doi]
AB  - OBJECTIVES Risk assessment of patients with aortic stenosis (AS) undergoing 
      aortic valve replacement (AVR) is challenging. We set out to determine the impact 
      of myocardial late gadolinium enhancement (LGE), as detected by cardiovascular 
      magnetic resonance (CMR), on postoperative outcomes following AVR. METHODS A 
      prospective observational study was conducted on patients undergoing CMR using 
      the LGE technique within 1 year of subsequent AVR. Patients were categorized into 
      absent, mid-wall or infarct patterns of LGE by independent observers blinded to 
      all clinical data, and data were collected with regard to 30-day mortality, major 
      adverse cardiac and cerebrovascular events (MACCE) and postoperative 
      complications. RESULTS A total of 63 patients were studied. Twenty-five patients 
      had no LGE; 20 had mid-wall LGE and 18 had an infarct pattern. The incidence of 
      MACCE, cerebrovascular accident (CVA) and heart block were significantly higher 
      in the mid-wall group compared with the other two groups (MACCE: 25 vs. 0 vs. 5%, 
      P = 0.014; CVA: 20 vs. 0 vs. 0%, P = 0.013; heart block: 30 vs. 4 vs. 12%, P = 
      0.050). Patients with no LGE had no 30-day MACCE events and no deaths up to 2 
      years of follow-up. CONCLUSIONS The myocardial LGE holds promise as a means of 
      predicting risk prior to AVR for AS.
FAU - Quarto, Cesare
AU  - Quarto C
AD  - Academic Department of Cardiothoracic Surgery, Royal Brompton Hospital, London, 
      UK. c.quarto@rbht.nhs.uk
FAU - Dweck, Marc R
AU  - Dweck MR
FAU - Murigu, Timothy
AU  - Murigu T
FAU - Joshi, Sanjiv
AU  - Joshi S
FAU - Melina, Giovanni
AU  - Melina G
FAU - Angeloni, Emiliano
AU  - Angeloni E
FAU - Prasad, Sanjay K
AU  - Prasad SK
FAU - Pepper, John R
AU  - Pepper JR
LA  - eng
GR  - FS/10/026/British Heart Foundation/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120417
PL  - England
TA  - Interact Cardiovasc Thorac Surg
JT  - Interactive cardiovascular and thoracic surgery
JID - 101158399
RN  - 0 (Contrast Media)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Analysis of Variance
MH  - Aortic Valve Stenosis/complications/*diagnosis/mortality/pathology/*surgery
MH  - Cerebrovascular Disorders/etiology
MH  - Chi-Square Distribution
MH  - *Contrast Media
MH  - Female
MH  - Fibrosis
MH  - *Gadolinium DTPA
MH  - Heart Block/etiology
MH  - Heart Valve Prosthesis Implantation/*adverse effects/mortality
MH  - Humans
MH  - London
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/complications/*diagnosis/mortality/pathology
MH  - Myocardium/*pathology
MH  - Predictive Value of Tests
MH  - Prospective Studies
MH  - Risk Assessment
MH  - Risk Factors
MH  - Treatment Outcome
PMC - PMC3380978
EDAT- 2012/04/20 06:00
MHDA- 2012/10/30 06:00
PMCR- 2013/07/01
CRDT- 2012/04/20 06:00
PHST- 2012/04/20 06:00 [entrez]
PHST- 2012/04/20 06:00 [pubmed]
PHST- 2012/10/30 06:00 [medline]
PHST- 2013/07/01 00:00 [pmc-release]
AID - ivs098 [pii]
AID - 10.1093/icvts/ivs098 [doi]
PST - ppublish
SO  - Interact Cardiovasc Thorac Surg. 2012 Jul;15(1):45-50. doi: 10.1093/icvts/ivs098. 
      Epub 2012 Apr 17.