PMID- 22515203
OWN - NLM
STAT- MEDLINE
DCOM- 20121001
LR  - 20120521
IS  - 1029-2292 (Electronic)
IS  - 0897-7194 (Linking)
VI  - 30
IP  - 3
DP  - 2012 Jun
TI  - Gastrocnemius-derived BDNF promotes motor function recovery in spinal cord 
      transected rats.
PG  - 167-75
LID - 10.3109/08977194.2012.678842 [doi]
AB  - This study evaluated the role of gastrocnemius-derived brain-derived neurotrophic 
      factor (BDNF) and possible mechanism in motor improvement in T10 spinal cord 
      transection (SCT) rats. There was complete paralysis in hindlimbs immediately 
      after SCT, followed by partial functional restoration with time going. The level 
      of BDNF but not its mRNA gradually increased in caudal stump after SCT, whereas a 
      significant increase in both BDNF and its mRNA was simultaneously seen in 
      gastrocnemius. Injection of BDNF antibody into the gastrocnemius significantly 
      decreased hindlimb locomotor function, downregulated the level of BDNF and its 
      mRNA together with extracellular signal-regulated kinase 1/2 (Erk1/2). Moreover, 
      ventral root ligation led to decrease both BDNF and Erk in caudal stump, 
      indicating BDNF transportation from gastrocnemius into the spinal cord. We 
      concluded that gastrocnemius-derived BDNF reduced motor functional deficits in 
      SCT rats through Erk signaling pathway. These novel findings suggested the usage 
      of BDNF in muscle for the treatment of spinal cord injury in clinic.
FAU - Gao, Li
AU  - Gao L
AD  - Department of Neurosurgery, Tangdu Hospital, Fourth Military Medical University, 
      Xi'an, People's Republic of China.
FAU - Li, Li-Hong
AU  - Li LH
FAU - Xing, Ru-Xin
AU  - Xing RX
FAU - Ou, Shan
AU  - Ou S
FAU - Liu, Guo-Dong
AU  - Liu GD
FAU - Wang, Yan-Ping
AU  - Wang YP
FAU - Zhang, Hua
AU  - Zhang H
FAU - Gao, Guo-Dong
AU  - Gao GD
FAU - Wang, Ting-Hua
AU  - Wang TH
LA  - eng
PT  - Journal Article
DEP - 20120419
PL  - England
TA  - Growth Factors
JT  - Growth factors (Chur, Switzerland)
JID - 9000468
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism/pharmacology/*therapeutic use
MH  - Female
MH  - Hindlimb/drug effects/*physiology
MH  - MAP Kinase Signaling System
MH  - Motor Activity/drug effects/*physiology
MH  - Muscle, Skeletal/*metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Spinal Cord/*metabolism
MH  - Spinal Cord Injuries/drug therapy
EDAT- 2012/04/21 06:00
MHDA- 2012/10/02 06:00
CRDT- 2012/04/21 06:00
PHST- 2012/04/21 06:00 [entrez]
PHST- 2012/04/21 06:00 [pubmed]
PHST- 2012/10/02 06:00 [medline]
AID - 10.3109/08977194.2012.678842 [doi]
PST - ppublish
SO  - Growth Factors. 2012 Jun;30(3):167-75. doi: 10.3109/08977194.2012.678842. Epub 
      2012 Apr 19.