PMID- 22515204
OWN - NLM
STAT- MEDLINE
DCOM- 20130411
LR  - 20120813
IS  - 1440-1754 (Electronic)
IS  - 1034-4810 (Linking)
VI  - 48
IP  - 8
DP  - 2012 Aug
TI  - A clinical audit of antithrombin concentrate use in a tertiary paediatric centre.
PG  - 681-4
LID - 10.1111/j.1440-1754.2012.02451.x [doi]
AB  - AIM:   The aim of this study was to investigate the clinical use of antithrombin 
      concentrate (ATC) in children and specifically to determine the current practice 
      of ATC administration, including dosing and indications for administration. 
      METHODS:   A clinical audit was performed of patients treated with ATC during two 
      12-month periods: 1 June 1999-1 June 2000 and 1 June 2009-1 June 2010. RESULTS:   
      Thirty-seven patients whose age ranged from 1 day to 13.5 years (median 30 days) 
      received a median of two doses (range 1-15) with a median dose of 40 units/kg 
      (range 1-200 units). The majority (90%) of patients were located in the intensive 
      care unit, and the major indication (76%) for use of the ATC was in the setting 
      of unfractionated heparin (UFH) resistance. Post-ATC administration, 32% of the 
      doses given resulted in antithrombin levels reaching age-specific normative 
      levels. Of the patients administered ATC with the aim of optimising UFH therapy, 
      28% of patients had their UFH dose reduced without any measurement of UFH effect. 
      CONCLUSIONS:   This data provides the basis for future investigations of the 
      specific biochemical changes accompanying ATC administration and the development 
      of paediatric-specific evidence-based guidelines for ATC use.
CI  - (c) 2012 The Authors. Journal of Paediatrics and Child Health (c) 2012 Paediatrics 
      and Child Health Division (Royal Australasian College of Physicians).
FAU - Kozul, Christina
AU  - Kozul C
AD  - Haematology Research Group, Murdoch Childrens Research Institute, Flemington 
      Road, Parkville, VIC 3052, Australia.
FAU - Newall, Fiona
AU  - Newall F
FAU - Monagle, Paul
AU  - Monagle P
FAU - Mertyn, Eliza
AU  - Mertyn E
FAU - Ignjatovic, Vera
AU  - Ignjatovic V
LA  - eng
PT  - Journal Article
DEP - 20120419
PL  - Australia
TA  - J Paediatr Child Health
JT  - Journal of paediatrics and child health
JID - 9005421
RN  - 0 (Anticoagulants)
RN  - 0 (Antithrombins)
SB  - IM
MH  - Adolescent
MH  - Anticoagulants/*administration & dosage/therapeutic use
MH  - Antithrombins/*administration & dosage/therapeutic use
MH  - Child
MH  - Child, Preschool
MH  - Clinical Audit
MH  - Female
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Intensive Care Units, Pediatric
MH  - Male
MH  - Tertiary Care Centers
EDAT- 2012/04/21 06:00
MHDA- 2013/04/12 06:00
CRDT- 2012/04/21 06:00
PHST- 2012/04/21 06:00 [entrez]
PHST- 2012/04/21 06:00 [pubmed]
PHST- 2013/04/12 06:00 [medline]
AID - 10.1111/j.1440-1754.2012.02451.x [doi]
PST - ppublish
SO  - J Paediatr Child Health. 2012 Aug;48(8):681-4. doi: 
      10.1111/j.1440-1754.2012.02451.x. Epub 2012 Apr 19.