PMID- 2251679
OWN - NLM
STAT- MEDLINE
DCOM- 19910117
LR  - 20190727
IS  - 0041-008X (Print)
IS  - 0041-008X (Linking)
VI  - 106
IP  - 1
DP  - 1990 Oct
TI  - 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-induced appetite suppression in the 
      Sprague-Dawley rat is not a direct effect on feed intake regulation in the brain.
PG  - 158-62
AB  - The most striking sign of acute toxicity of TCDD in animals is a progressive 
      reduction of feed intake, accompanied by loss of body weight eventually resulting 
      in death. The mechanism(s) of this voluntary feed refusal is (are) not known but 
      it is generally accepted that both centrally and peripherally (via feedback) 
      acting anorectic agents exert their effect(s) in the hypothalamus. In this study 
      direct administration into the lateral cerebral ventricle of rats resulted in 
      much higher concentrations of TCDD in the hypothalamus and also in other regions 
      of the brain than after a lethal intravenous (iv) injection. While rats injected 
      iv displayed the expected cachectic syndrome, intracerebroventricularly 
      (icv)-dosed animals ate and gained weight normally. These findings preclude the 
      possibility of a direct effect of TCDD on appetite-regulating areas of the brain. 
      Moreover, these results require the assumption that the appetite suppressive 
      effect of TCDD is due to a (feedback) mechanism originating in the periphery.
FAU - Stahl, B U
AU  - Stahl BU
AD  - Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas 
      Medical Center, Kansas City 66103.
FAU - Rozman, K
AU  - Rozman K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Toxicol Appl Pharmacol
JT  - Toxicology and applied pharmacology
JID - 0416575
RN  - 0 (Polychlorinated Dibenzodioxins)
SB  - IM
MH  - Animals
MH  - Appetite/*drug effects
MH  - Body Weight/drug effects
MH  - Brain/*drug effects
MH  - Injections, Intravenous
MH  - Injections, Intraventricular
MH  - Male
MH  - Polychlorinated Dibenzodioxins/administration & dosage/pharmacokinetics/*toxicity
MH  - Rats
MH  - Rats, Inbred Strains
EDAT- 1990/10/01 00:00
MHDA- 1990/10/01 00:01
CRDT- 1990/10/01 00:00
PHST- 1990/10/01 00:00 [pubmed]
PHST- 1990/10/01 00:01 [medline]
PHST- 1990/10/01 00:00 [entrez]
AID - 10.1016/0041-008x(90)90116-c [doi]
PST - ppublish
SO  - Toxicol Appl Pharmacol. 1990 Oct;106(1):158-62. doi: 
      10.1016/0041-008x(90)90116-c.