PMID- 22516988
OWN - NLM
STAT- MEDLINE
DCOM- 20130628
LR  - 20171116
IS  - 1671-167X (Print)
IS  - 1671-167X (Linking)
VI  - 44
IP  - 2
DP  - 2012 Apr 18
TI  - [Measurement and clinical significance of serum monocyte chemoattractant 
      protein-1 in patients with polymyosits/dermatomyosits].
PG  - 204-8
AB  - OBJECTIVE: To analyze the correlated clinical significance by testing the serum 
      monocyte chemoattractant protein-1 (MCP-1) levels of patients with 
      polymyositis/dermatomyositis (PM/DM). METHODS: The sera from 100 adult PM/DM 
      patients, 20 patients with pulmonary infection and 42 healthy controls were 
      selected. The serum MCP-1 concentrations were detected by enzyme-linked 
      immunosorbent assay (ELISA). The correlations between serum MCP-1 levels and 
      clinical features or laboratory examinations of PM/DM patients were investigated. 
      RESULTS: The serum levels of MCP-1 were (1 869 +/-1 590) ng/L, (1 349+/-1 303) ng/L, 
      (493+/-255) ng/L and (256+/-144) ng/L in PM/DM patients with interstitial lung 
      disease (ILD) and without ILD, patients with infectious lung disease and healthy 
      controls, respectively. Serum MCP-1 levels in the PM/DM patients with ILD were 
      significantly higher than those of the PM/DM patients without ILD, patients with 
      infectious lung disease and healthy controls (all P values<0.01). Significant 
      correlations were found between the elevated levels of serum MCP-1 and the 
      presence of ILD in the patients with PM/DM (chi2=9.6, P<0.01). The sensitivity and 
      specificity of serum abnormal MCP-1 levels for ILD in the patients with PM/DM 
      were 60.7% and 68.2%, respectively. The incidence of fever, arthritis, decreased 
      %DL(CO) , erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and 
      serum ferritin were significantly higher in the MCP-1 raised group than in the 
      MCP-1 normal group (all P values<0.005). Additionally, Spearman rank correlation 
      analysis showed that serum MCP-1 levels were positively correlated with serum 
      ferritin in peripheral blood in the patients with PM/DM. CONCLUSION: The levels 
      of serum MCP-1 are significantly elevated in PM/DM and it is significantly 
      associated with ILD complication, and may contribute to the early differentiation 
      of ILD from lung infectious disease.
FAU - Chen, Fang
AU  - Chen F
AD  - Department of Rheumatology, China-Japan Friendship Hospital, Beijing 100029, 
      China.
FAU - Shu, Xiao-ming
AU  - Shu XM
FAU - Wang, Dong-xue
AU  - Wang DX
FAU - Wang, Guo-chun
AU  - Wang GC
FAU - Lu, Xin
AU  - Lu X
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Beijing Da Xue Xue Bao Yi Xue Ban
JT  - Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health 
      sciences
JID - 101125284
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Chemokine CCL2/*blood
MH  - Dermatomyositis/*blood/complications
MH  - Diagnosis, Differential
MH  - Female
MH  - Humans
MH  - Lung Diseases, Interstitial/diagnosis/*etiology
MH  - Male
MH  - Middle Aged
MH  - Pneumonia/diagnosis
MH  - Polymyositis/*blood/complications
MH  - Young Adult
EDAT- 2012/04/21 06:00
MHDA- 2013/07/03 06:00
CRDT- 2012/04/21 06:00
PHST- 2012/04/21 06:00 [entrez]
PHST- 2012/04/21 06:00 [pubmed]
PHST- 2013/07/03 06:00 [medline]
PST - ppublish
SO  - Beijing Da Xue Xue Bao Yi Xue Ban. 2012 Apr 18;44(2):204-8.