PMID- 22517274
OWN - NLM
STAT- MEDLINE
DCOM- 20120814
LR  - 20131121
IS  - 1421-9913 (Electronic)
IS  - 0014-3022 (Linking)
VI  - 67
IP  - 4
DP  - 2012
TI  - Evaluation of systemic redox states in patients carrying the MELAS A3243G 
      mutation in mitochondrial DNA.
PG  - 232-7
LID - 10.1159/000336568 [doi]
AB  - BACKGROUND/AIMS: To clarify the change of systemic redox states in patients 
      carrying the A3243G mutation in mitochondrial DNA (A3243G), we evaluated 
      oxidative stress and antioxidant activity in the serum of patients. METHODS: 
      Oxidative stress and antioxidant activity in the serum samples obtained from 14 
      patients carrying A3243G and from 34 healthy controls were analyzed using the 
      diacron-reactive oxygen metabolites (d-ROMs) and biological antioxidant potential 
      (BAP) tests, respectively. RESULTS: The mean d-ROMs level of all patients was 
      significantly greater than that of the controls (p < 0.005), and the mean 
      BAP/d-ROMs ratio of all patients was significantly lower than that of the 
      controls (p < 0.02). In the patients with a history of stroke-like episodes (n = 
      10), both mean d-ROMs and BAP levels were increased compared with those of the 
      controls (both p < 0.01). The mean BAP level of the patients without a history of 
      stroke-like episodes (n = 4) was significantly decreased compared with that of 
      the controls (p < 0.001), but the mean d-ROMs levels were not significantly 
      different. CONCLUSION: d-ROMs and BAP tests indicated that patients carrying 
      A3243G are always exposed to underlying oxidative stress, even at a remission 
      state of stroke-like episodes.
CI  - Copyright (c) 2012 S. Karger AG, Basel.
FAU - Ikawa, Masamichi
AU  - Ikawa M
AD  - Second Department of Internal Medicine, Faculty of Medical Sciences, University 
      of Fukui, Fukui, Japan.
FAU - Arakawa, Kenichiro
AU  - Arakawa K
FAU - Hamano, Tadanori
AU  - Hamano T
FAU - Nagata, Miwako
AU  - Nagata M
FAU - Nakamoto, Yasunari
AU  - Nakamoto Y
FAU - Kuriyama, Masaru
AU  - Kuriyama M
FAU - Koga, Yasutoshi
AU  - Koga Y
FAU - Yoneda, Makoto
AU  - Yoneda M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120314
PL  - Switzerland
TA  - Eur Neurol
JT  - European neurology
JID - 0150760
RN  - 0 (Antioxidants)
RN  - 0 (DNA, Mitochondrial)
RN  - 0 (Reactive Oxygen Species)
RN  - BBX060AN9V (Hydrogen Peroxide)
RN  - OF5P57N2ZX (Alanine)
RN  - TE7660XO1C (Glycine)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Alanine/genetics
MH  - Antioxidants/metabolism
MH  - DNA, Mitochondrial/*genetics
MH  - Female
MH  - Glycine/genetics
MH  - Humans
MH  - Hydrogen Peroxide/blood
MH  - MELAS Syndrome/blood/*genetics/*physiopathology
MH  - Male
MH  - Mutation/*genetics
MH  - Oxidation-Reduction
MH  - Oxidative Stress/*genetics
MH  - Reactive Oxygen Species/blood
MH  - Statistics, Nonparametric
MH  - Young Adult
EDAT- 2012/04/21 06:00
MHDA- 2012/08/15 06:00
CRDT- 2012/04/21 06:00
PHST- 2011/08/08 00:00 [received]
PHST- 2012/01/14 00:00 [accepted]
PHST- 2012/04/21 06:00 [entrez]
PHST- 2012/04/21 06:00 [pubmed]
PHST- 2012/08/15 06:00 [medline]
AID - 000336568 [pii]
AID - 10.1159/000336568 [doi]
PST - ppublish
SO  - Eur Neurol. 2012;67(4):232-7. doi: 10.1159/000336568. Epub 2012 Mar 14.