PMID- 22517381
OWN - NLM
STAT- MEDLINE
DCOM- 20130423
LR  - 20200320
IS  - 1473-5873 (Electronic)
IS  - 0955-8829 (Linking)
VI  - 22
IP  - 5
DP  - 2012 Oct
TI  - BDNF expression in lymphoblastoid cell lines carrying BDNF SNPs associated with 
      bipolar disorder.
PG  - 253-5
LID - 10.1097/YPG.0b013e328353ae66 [doi]
AB  - OBJECTIVE: To determine whether single nucleotide polymorphisms (SNPs) of the 
      brain-derived neurotrophic factor (BDNF) that have been associated with bipolar 
      illness are associated with physiological dysfunction. METHODS: Lymphoblastoid 
      cell lines (n=30) obtained from bipolar I individuals carrying zero, one, or two 
      copies of a BDNF SNP associated with bipolar illness (rs12273363) were utilized. 
      RESULTS: Proapoptotic stressors of serum deprivation alone, or serum deprivation 
      combined with the sodium ionophore, monensin, did not alter intracellular 
      proBDNF. Monensin treatment increased mature-BDNF (mBDNF) protein levels 
      (P<0.05). There were no differences related to the presence of SNP or copy 
      number. CONCLUSION: rs12273363 does not appear to have functional consequences 
      that would involve its role in bipolar illness.
FAU - Gao, Yonglin
AU  - Gao Y
AD  - Mood Disorder Research Program, Department of Psychiatry and Behavioral Science, 
      School of Medicine, University of Louisville, Louisville, Kentucky 40292, USA.
FAU - Galante, Mathew
AU  - Galante M
FAU - El-Mallakh, James
AU  - El-Mallakh J
FAU - Nurnberger, John I Jr
AU  - Nurnberger JI Jr
FAU - Delamere, Nicholas A
AU  - Delamere NA
FAU - Lei, Zhenmin
AU  - Lei Z
FAU - El-Mallakh, Rif S
AU  - El-Mallakh RS
CN  - BiGS Consortium
LA  - eng
PT  - Journal Article
PL  - England
TA  - Psychiatr Genet
JT  - Psychiatric genetics
JID - 9106748
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Apoptosis/genetics
MH  - Bipolar Disorder/*genetics
MH  - Brain-Derived Neurotrophic Factor/*genetics/*metabolism
MH  - Cell Line
MH  - DNA Fragmentation
MH  - Female
MH  - Humans
MH  - Lymphocytes/*metabolism
MH  - Male
MH  - Polymorphism, Single Nucleotide/*genetics
FIR - Kelsoe, John R
IR  - Kelsoe JR
FIR - Greenwood, Tiffany A
IR  - Greenwood TA
FIR - Nievergelt, Caroline M
IR  - Nievergelt CM
FIR - McKinney, Rebecca
IR  - McKinney R
FIR - Shilling, Paul D
IR  - Shilling PD
FIR - Schork, Nicholas J
IR  - Schork NJ
FIR - Smith, Erin N
IR  - Smith EN
FIR - Bloss, Cinnamon S
IR  - Bloss CS
FIR - Nurnberger, John I Jr
IR  - Nurnberger JI Jr
FIR - Edenberg, Howard J
IR  - Edenberg HJ
FIR - Foroud, Tatiana
IR  - Foroud T
FIR - Koller, Daniel L
IR  - Koller DL
FIR - Gershon, Elliot S
IR  - Gershon ES
FIR - Liu, Chunyu
IR  - Liu C
FIR - Badner, Judith A
IR  - Badner JA
FIR - Scheftner, William A
IR  - Scheftner WA
FIR - Lawson, William B
IR  - Lawson WB
FIR - Nwulia, Evaristus A
IR  - Nwulia EA
FIR - Hipolito, Maria
IR  - Hipolito M
FIR - Coryell, William
IR  - Coryell W
FIR - Rice, John
IR  - Rice J
FIR - Byerley, William
IR  - Byerley W
FIR - McMahon, Francis J
IR  - McMahon FJ
FIR - Schulze, Thomas G
IR  - Schulze TG
FIR - Berrettini, Wade H
IR  - Berrettini WH
FIR - Potash, James B
IR  - Potash JB
FIR - Zandi, Peter P
IR  - Zandi PP
FIR - Mahon, Pamela B
IR  - Mahon PB
FIR - McInnis, Melvin G
IR  - McInnis MG
FIR - Zollner, Sebastian
IR  - Zollner S
FIR - Zhang, Peng
IR  - Zhang P
FIR - Craig, David W
IR  - Craig DW
FIR - Szelinger, Szabolcs
IR  - Szelinger S
FIR - Barrett, Thomas B
IR  - Barrett TB
EDAT- 2012/04/21 06:00
MHDA- 2013/04/24 06:00
CRDT- 2012/04/21 06:00
PHST- 2012/04/21 06:00 [entrez]
PHST- 2012/04/21 06:00 [pubmed]
PHST- 2013/04/24 06:00 [medline]
AID - 10.1097/YPG.0b013e328353ae66 [doi]
PST - ppublish
SO  - Psychiatr Genet. 2012 Oct;22(5):253-5. doi: 10.1097/YPG.0b013e328353ae66.