PMID- 2251950 OWN - NLM STAT- MEDLINE DCOM- 19910117 LR - 20181130 IS - 0001-6276 (Print) IS - 0001-6276 (Linking) VI - 12 IP - 4 DP - 1990 Aug TI - Exaggerated spontaneous release of tumor necrosis factor-alpha/cachectin in patients with migraine without aura. PG - 257-63 AB - Serum levels of tumor necrosis factor (TNF)-alpha/cachectin have been evaluated in 20 patients with Migraine without Aura (MwA) versus 17 patients with Chronic Type Tension Headache (CTTH). Results show an exaggerated release of TNF-alpha/cachectin in sera of patients affected by MwA, while in CTTH patients TNF serum concentration is comparable to that observed in normal donors. Some hypotheses are formulated in order to clarify the TNF-alpha/cachectin spontaneous production and its biological significance in patients with MwA. FAU - Covelli, V AU - Covelli V AD - Cattedra di Immunologia, Facolta di Medicina e Chirurgia, Bari, Italy. FAU - Munno, I AU - Munno I FAU - Pellegrino, N M AU - Pellegrino NM FAU - Di Venere, A AU - Di Venere A FAU - Jirillo, E AU - Jirillo E FAU - Buscaino, G A AU - Buscaino GA LA - eng PT - Journal Article PL - Italy TA - Acta Neurol (Napoli) JT - Acta neurologica JID - 0421100 RN - 0 (Tumor Necrosis Factor-alpha) SB - IM MH - Adult MH - Chronic Disease MH - Female MH - Headache/*blood MH - Humans MH - Male MH - Middle Aged MH - Migraine Disorders/*blood MH - Tumor Necrosis Factor-alpha/*metabolism EDAT- 1990/08/01 00:00 MHDA- 1990/08/01 00:01 CRDT- 1990/08/01 00:00 PHST- 1990/08/01 00:00 [pubmed] PHST- 1990/08/01 00:01 [medline] PHST- 1990/08/01 00:00 [entrez] PST - ppublish SO - Acta Neurol (Napoli). 1990 Aug;12(4):257-63.