PMID- 22519948
OWN - NLM
STAT- MEDLINE
DCOM- 20121031
LR  - 20161125
IS  - 1502-7708 (Electronic)
IS  - 0036-5521 (Linking)
VI  - 47
IP  - 7
DP  - 2012 Jul
TI  - A prospective evaluation of the role of transient elastography for the detection 
      of hepatic fibrosis in type 2 diabetes without overt liver disease.
PG  - 836-41
LID - 10.3109/00365521.2012.677955 [doi]
AB  - BACKGROUND: Type 2 diabetes mellitus (T2DM) is a major risk factor for the 
      development of non-alcoholic fatty liver disease (NAFLD) and subsequently hepatic 
      fibrosis. Transient elastography (TE) is a rapid, reproducible non-invasive test 
      that may be appropriate as a screening tool for the presence of hepatic fibrosis. 
      AIM: Assess the utility of TE as a screening tool for the presence of hepatic 
      fibrosis in a T2DM population with no known liver disease. METHODS: T2DM patients 
      without known liver disease were included. Patients were assessed with TE in 
      addition to biochemical parameters. RESULTS: A successful TE evaluation could be 
      obtained in 74 of 81 (91%) included subjects. Of these, 26 (35%) had a liver 
      stiffness measurement (LSM) >/= 7.65 kPa. Sixteen of these subjects had 
      confirmatory liver biopsies with significant (>/= F2 fibrosis) present in 12 (75%) 
      and cirrhosis diagnosed in 2 subjects. 15/16 (94%) had histological 
      steatohepatitis. Compared with those with a lower LSM, subjects with an LSM >/= 
      7.65 kPa had higher ALT levels (38.0 +/- 21.7 vs 26.1 +/- 11.1 U/L, p = 0.021) and 
      increased prevalence of hepatic steatosis by ultrasound (85% vs 63%, p = 0.005). 
      CONCLUSION: Significant hepatic fibrosis in the T2DM population is frequently 
      under-recognized. TE may be a feasible tool for the screening of T2DM patients 
      for the presence of hepatic fibrosis.
FAU - Casey, Stephen P
AU  - Casey SP
AD  - Departments of Gastroenterology, Alfred Hospital, Melbourne, Vic, Australia.
FAU - Kemp, William W
AU  - Kemp WW
FAU - McLean, Catriona A
AU  - McLean CA
FAU - Topliss, Duncan J
AU  - Topliss DJ
FAU - Adams, Leon A
AU  - Adams LA
FAU - Roberts, Stuart K
AU  - Roberts SK
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
DEP - 20120423
PL  - England
TA  - Scand J Gastroenterol
JT  - Scandinavian journal of gastroenterology
JID - 0060105
RN  - EC 2.6.1.2 (Alanine Transaminase)
SB  - IM
MH  - Aged
MH  - Alanine Transaminase/blood
MH  - Algorithms
MH  - Biopsy
MH  - Body Mass Index
MH  - Chi-Square Distribution
MH  - Decision Support Techniques
MH  - Diabetes Mellitus, Type 2/*complications
MH  - *Elasticity Imaging Techniques
MH  - Fatty Liver/classification/complications/*diagnostic imaging
MH  - Female
MH  - Humans
MH  - Liver Cirrhosis/blood/complications/*diagnosis
MH  - Male
MH  - Mass Screening
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - Statistics, Nonparametric
MH  - Waist Circumference
EDAT- 2012/04/24 06:00
MHDA- 2012/11/01 06:00
CRDT- 2012/04/24 06:00
PHST- 2012/04/24 06:00 [entrez]
PHST- 2012/04/24 06:00 [pubmed]
PHST- 2012/11/01 06:00 [medline]
AID - 10.3109/00365521.2012.677955 [doi]
PST - ppublish
SO  - Scand J Gastroenterol. 2012 Jul;47(7):836-41. doi: 10.3109/00365521.2012.677955. 
      Epub 2012 Apr 23.