PMID- 22520398
OWN - NLM
STAT- MEDLINE
DCOM- 20121009
LR  - 20161125
IS  - 1873-460X (Electronic)
IS  - 1056-8727 (Linking)
VI  - 26
IP  - 3
DP  - 2012 May-Jun
TI  - Cerebral haemodynamics, cognition and brain volumes in patients with type 2 
      diabetes.
PG  - 205-9
LID - 10.1016/j.jdiacomp.2012.03.021 [doi]
AB  - BACKGROUND: Type 2 diabetes mellitus (T2DM) is associated with cognitive 
      impairment and brain abnormalities on MRI. The underlying mechanisms are unclear. 
      We examined the relationship between cerebral haemodynamics (cerebral blood flow 
      (CBF) and cerebrovascular reactivity (CVR)) and cognitive performance and brain 
      volumes in patients with T2DM, at baseline and after four years. METHODS: 114 
      patients with T2DM, aged 56-80 years, underwent a detailed cognitive assessment 
      and MRI scan. In 68 patients the evaluation was repeated after four years. CBF 
      (two-dimensional flow-encoded phase-contrast MRI) and CVR (carbogen breathing 
      response middle cerebral artery; transcranial Doppler) were measured at baseline. 
      Cognitive performance was expressed as composite z-score and regression based 
      index score. Brain volumes were measured on MRI by automated segmentation. The 
      relationship of haemodynamics with cognition and brain volumes was examined with 
      linear regression analyses adjusted for age, sex and IQ. RESULTS: Mean CVR was 
      51.8% +/- 18.0% and mean rCBF 53.3 +/- 11.3 ml/min/100 ml brain tissue. CBF was 
      associated with baseline cognitive performance (standardized regression 
      coefficient beta (95% CI): 0.17 (0.00; 0.32) and total brain volume (0.23 (0.05; 
      0.41)). No correlation was found between CVR and baseline cognitive performance. 
      Neither CBF nor CVR predicted change in cognition (CBF 0.11 (-0.21; 0.44); CVR 
      0.07 (-0.21; 0.36)) or total brain volume (CBF 0.09 (-0.22; 0.39); CVR 0.13 
      (-0.13; 0.40)) over four years. CONCLUSIONS: CBF was associated with impaired 
      cognition and total brain volume in cross-sectional analyses, but did not predict 
      changes in cognition or brain volumes over time. Apparently, alterations in 
      cerebral haemodynamics play no major etiological role in cognitive decline or 
      change in brain volumes in non-demented individuals with T2DM.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Brundel, Manon
AU  - Brundel M
AD  - Department of Neurology, Rudolf Magnus Institute of Neuroscience, University 
      Medical Center, Utrecht, The Netherlands. m.brundel-2@umcutrecht.nl
FAU - van den Berg, Esther
AU  - van den Berg E
FAU - Reijmer, Yael D
AU  - Reijmer YD
FAU - de Bresser, Jeroen
AU  - de Bresser J
FAU - Kappelle, L Jaap
AU  - Kappelle LJ
FAU - Biessels, Geert Jan
AU  - Biessels GJ
CN  - Utrecht Diabetic Encephalopathy Study group
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120418
PL  - United States
TA  - J Diabetes Complications
JT  - Journal of diabetes and its complications
JID - 9204583
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Brain/blood supply/diagnostic imaging/*pathology/*physiopathology
MH  - Case-Control Studies
MH  - Cerebrovascular Circulation/*physiology
MH  - Cognition/*physiology
MH  - Cognition Disorders/etiology/physiopathology
MH  - Diabetes Mellitus, Type 2/complications/pathology/*physiopathology
MH  - Female
MH  - Hemodynamics/*physiology
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Neuropsychological Tests
MH  - Organ Size/physiology
MH  - Radiography
EDAT- 2012/04/24 06:00
MHDA- 2012/10/10 06:00
CRDT- 2012/04/24 06:00
PHST- 2011/06/14 00:00 [received]
PHST- 2012/03/11 00:00 [revised]
PHST- 2012/03/19 00:00 [accepted]
PHST- 2012/04/24 06:00 [entrez]
PHST- 2012/04/24 06:00 [pubmed]
PHST- 2012/10/10 06:00 [medline]
AID - S1056-8727(12)00061-X [pii]
AID - 10.1016/j.jdiacomp.2012.03.021 [doi]
PST - ppublish
SO  - J Diabetes Complications. 2012 May-Jun;26(3):205-9. doi: 
      10.1016/j.jdiacomp.2012.03.021. Epub 2012 Apr 18.