PMID- 22521150
OWN - NLM
STAT- MEDLINE
DCOM- 20130122
LR  - 20131121
IS  - 1873-2402 (Electronic)
IS  - 0006-3223 (Linking)
VI  - 72
IP  - 6
DP  - 2012 Sep 15
TI  - Maternal care influences hippocampal N-methyl-D-aspartate receptor function and 
      dynamic regulation by corticosterone in adulthood.
PG  - 491-8
LID - 10.1016/j.biopsych.2012.03.016 [doi]
AB  - BACKGROUND: Variations in maternal care in the rat associate with robust 
      differences in hippocampal development and synaptic plasticity in the offspring. 
      Maternal care also influences pituitary-adrenal stress responses and 
      corticosterone (CORT) regulation of hippocampal plasticity. N-methyl-D-aspartate 
      receptors (NMDAR) regulate synaptic plasticity, and NMDAR function is modulated 
      by stress and CORT. We hypothesized that altered NMDAR function underlies the 
      interaction of maternal and stress effects on hippocampal synaptic plasticity. 
      METHODS: We used electrophysiology and western blot to examine NMDAR synaptic 
      function/expression and NMDAR-dependent long-term potentiation (LTP) in adult 
      offspring of mothers that varied in the frequency of pup licking/grooming (LG) 
      (i.e., High or Low LG). RESULTS: Basal NMDAR synaptic function was enhanced in 
      the hippocampal dentate gyrus (DG) of adult Low LG offspring. Synaptic expression 
      of NMDAR but not alpha-amino-3-hydroxy-methyl-4-isoxazole propionic acid receptors 
      was also increased. Stress level CORT (100 nmol/L) rapidly (< 20 min) and 
      robustly increased NMDAR function in High LG offspring, eliminating the maternal 
      effect. Corticosterone did not affect NMDAR function in Low LG offspring. Bovine 
      serum albumin-conjugated CORT reproduced the CORT effect in High LG offspring, 
      implicating a membrane-bound corticosteroid receptor. NMDAR hyperfunction might 
      impair synaptic plasticity. Partial NMDAR antagonism by low concentration 
      DL-2-Amino-5-phosphonopentanoic acid rescued a basal LTP deficit in Low LG 
      offspring and inhibited LTP in High LG offspring. CONCLUSIONS: Low LG offspring 
      exhibit basally elevated NMDAR function coupled with insensitivity to CORT 
      modulation indicative of a chronic alteration of NMDAR function. Elevated NMDAR 
      function in the hippocampus might underlie impaired LTP in Low LG offspring.
CI  - Copyright (c) 2012 Society of Biological Psychiatry. Published by Elsevier Inc. All 
      rights reserved.
FAU - Bagot, Rosemary C
AU  - Bagot RC
AD  - Neuroscience Division, Douglas Mental Health University Institute, McGill 
      University, Montreal, Quebec, Canada.
FAU - Tse, Yiu Chung
AU  - Tse YC
FAU - Nguyen, Huy-Binh
AU  - Nguyen HB
FAU - Wong, Alice S
AU  - Wong AS
FAU - Meaney, Michael J
AU  - Meaney MJ
FAU - Wong, Tak Pan
AU  - Wong TP
LA  - eng
GR  - MOP-106649/Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120421
PL  - United States
TA  - Biol Psychiatry
JT  - Biological psychiatry
JID - 0213264
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 77521-29-0 (alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid)
RN  - W980KJ009P (Corticosterone)
SB  - IM
CIN - Biol Psychiatry. 2012 Sep 15;72(6):432-3. PMID: 22906752
MH  - Animals
MH  - Blotting, Western
MH  - Corticosterone/*metabolism/pharmacology
MH  - Dentate Gyrus/drug effects/*metabolism
MH  - Electrophysiology/methods
MH  - Female
MH  - Grooming/*physiology
MH  - Long-Term Potentiation/drug effects/*physiology
MH  - Male
MH  - Maternal Behavior/*physiology
MH  - Neuronal Plasticity/drug effects/*physiology
MH  - Rats
MH  - Rats, Long-Evans
MH  - Receptors, N-Methyl-D-Aspartate/drug effects/*metabolism
MH  - alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid/antagonists & 
      inhibitors/metabolism
EDAT- 2012/04/24 06:00
MHDA- 2013/01/23 06:00
CRDT- 2012/04/24 06:00
PHST- 2011/11/29 00:00 [received]
PHST- 2012/03/15 00:00 [revised]
PHST- 2012/03/18 00:00 [accepted]
PHST- 2012/04/24 06:00 [entrez]
PHST- 2012/04/24 06:00 [pubmed]
PHST- 2013/01/23 06:00 [medline]
AID - S0006-3223(12)00264-8 [pii]
AID - 10.1016/j.biopsych.2012.03.016 [doi]
PST - ppublish
SO  - Biol Psychiatry. 2012 Sep 15;72(6):491-8. doi: 10.1016/j.biopsych.2012.03.016. 
      Epub 2012 Apr 21.