PMID- 22521161
OWN - NLM
STAT- MEDLINE
DCOM- 20121017
LR  - 20131121
IS  - 1879-1379 (Electronic)
IS  - 0022-3956 (Linking)
VI  - 46
IP  - 6
DP  - 2012 Jun
TI  - Brain-derived neurotrophic factor Val66Met polymorphism and obsessive-compulsive 
      symptoms in Egyptian schizophrenia patients.
PG  - 762-6
LID - 10.1016/j.jpsychires.2012.03.007 [doi]
AB  - BACKGROUND: Brain-derived neurotrophic factor (BDNF) has been advanced as a 
      candidate gene for schizophrenia. BDNF promote the function and growth of 5-HT 
      neurons in the brain and modulate the synaptic plasticity of DRD3-secreting 
      neurons in the striatum, suggesting involvement of BDNF in the mediation of 
      obsessive-compulsive disorder. OBJECTIVES: To test the hypothesis that the BDNF 
      Val66Met polymorphism influence obsessive-compulsive symptoms (OCS) in 
      schizophrenia, we examined the association between the BDNF Val66Met genotypes 
      and OCS in a group of patients with schizophrenia. METHODS: 320 schizophrenia 
      patients were assessed using the Yale-Brown Obsessive-Compulsive Scale (YBOCS). 
      BDNF Val66Met polymorphism was genotyped using PCR-RFLP method, and severity of 
      OCS were compared between the genotype groups. RESULTS: Out of the 320 
      schizophrenia patients, 120 patients (37.5%) had significant OCS. There was a 
      significant excess of valine allele in the schizophrenia with-OCS group compared 
      to the without-OCS group. The mean YBOCS scores were significantly different 
      among the three genotype groups. Val/Val homozygote patients had higher mean 
      YBOCS scores compared to Val/Met genotype (p = 0.0001) as well as to the Met/Met 
      homozygote group (p = 0.003). CONCLUSION: Our data suggested an association 
      between BDNF Val66Met polymorphism and OCS in Egyptian schizophrenia patients.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Hashim, Haytham M
AU  - Hashim HM
AD  - Department of Psychiatry, Faculty of Medicine, Zagazig University, Zagazig, 
      Egypt.
FAU - Fawzy, Nagy
AU  - Fawzy N
FAU - Fawzi, Mohab M
AU  - Fawzi MM
FAU - Karam, Rehab A
AU  - Karam RA
LA  - eng
PT  - Journal Article
DEP - 20120421
PL  - England
TA  - J Psychiatr Res
JT  - Journal of psychiatric research
JID - 0376331
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - AE28F7PNPL (Methionine)
RN  - HG18B9YRS7 (Valine)
SB  - IM
MH  - Adult
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - DNA Mutational Analysis
MH  - Egypt/epidemiology
MH  - Female
MH  - Gene Frequency
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Methionine/*genetics
MH  - Obsessive-Compulsive Disorder/etiology/*genetics
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Psychiatric Status Rating Scales
MH  - Schizophrenia/complications/genetics
MH  - Statistics, Nonparametric
MH  - Valine/*genetics
MH  - Young Adult
EDAT- 2012/04/24 06:00
MHDA- 2012/10/18 06:00
CRDT- 2012/04/24 06:00
PHST- 2011/08/06 00:00 [received]
PHST- 2012/02/29 00:00 [revised]
PHST- 2012/03/06 00:00 [accepted]
PHST- 2012/04/24 06:00 [entrez]
PHST- 2012/04/24 06:00 [pubmed]
PHST- 2012/10/18 06:00 [medline]
AID - S0022-3956(12)00089-1 [pii]
AID - 10.1016/j.jpsychires.2012.03.007 [doi]
PST - ppublish
SO  - J Psychiatr Res. 2012 Jun;46(6):762-6. doi: 10.1016/j.jpsychires.2012.03.007. 
      Epub 2012 Apr 21.