PMID- 22521589
OWN - NLM
STAT- MEDLINE
DCOM- 20121016
LR  - 20131121
IS  - 1873-7544 (Electronic)
IS  - 0306-4522 (Linking)
VI  - 213
DP  - 2012 Jun 28
TI  - Photoperiod and stress regulation of corticosteroid receptor, brain-derived 
      neurotrophic factor, and glucose transporter GLUT3 mRNA in the hippocampus of 
      male Siberian hamsters (Phodopus sungorus).
PG  - 106-11
LID - 10.1016/j.neuroscience.2012.03.043 [doi]
AB  - In response to changing day lengths, small photoperiodic rodents have evolved a 
      suite of adaptations to survive the energetic bottlenecks of winter. Among these 
      adaptations are changes in metabolism, adiposity, and energy balance. Whereas 
      hypothalamic and neuroendocrine regulation of these adaptations has been 
      extensively studied, the impact of day length, and interaction of day length and 
      stress, on the energy balance of neurons within the central nervous system 
      remains unspecified. Thus, we exposed male Siberian hamsters (Phodopus sungorus) 
      to either short or long day lengths for 14 weeks to induce the full suite of 
      adaptive responses, exposed them to 4h of restraint, and then measured relative 
      mRNA expression in the hippocampus for low- and high-affinity glucocorticoid 
      receptors (glucocorticoid receptor (GR), mineralocorticoid receptor (MR)), 
      brain-derived neurotrophic factor (BDNF), and the neuron-specific glucose 
      transporter GLUT3. Independent of photoperiod, restraint elevated plasma cortisol 
      (CORT) concentrations and reduced expression of GR, MR, and BDNF. Neither 
      restraint nor photoperiod significantly altered GLUT3 expression. Among all 
      groups, plasma cortisol concentrations were negatively correlated with GR and MR 
      expression. MR, BDNF, and GLUT3 levels were positively correlated with one 
      another, even when controlling for photoperiod and CORT. Taken together, these 
      results suggest that, as peripheral energy balance changes across day length in 
      this photoperiodic species, the neurons of the hippocampus do not alter relative 
      gene expression levels of three proteins involved in monitoring neuronal glucose 
      regulation and morphology.
CI  - Copyright (c) 2012 IBRO. Published by Elsevier Ltd. All rights reserved.
FAU - Walton, J C
AU  - Walton JC
AD  - Department of Neuroscience, The Ohio State University Wexner Medical Center, 
      Columbus, OH 43210, USA. walton.315@osu.edu
FAU - Grier, A J
AU  - Grier AJ
FAU - Weil, Z M
AU  - Weil ZM
FAU - Nelson, R J
AU  - Nelson RJ
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20120417
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Glucose Transporter Type 3)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Steroid)
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - Adaptation, Physiological/physiology
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*biosynthesis
MH  - Circadian Rhythm/physiology
MH  - Cricetinae
MH  - Energy Metabolism/physiology
MH  - Gene Expression Profiling
MH  - Glucose Transporter Type 3/*biosynthesis/genetics
MH  - Hippocampus/*metabolism
MH  - Hydrocortisone/blood
MH  - Male
MH  - Neurons/metabolism
MH  - Phodopus
MH  - *Photoperiod
MH  - RNA, Messenger/analysis
MH  - Receptors, Steroid/*biosynthesis
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Stress, Psychological/*metabolism
EDAT- 2012/04/24 06:00
MHDA- 2012/10/17 06:00
CRDT- 2012/04/24 06:00
PHST- 2012/02/10 00:00 [received]
PHST- 2012/03/27 00:00 [revised]
PHST- 2012/03/30 00:00 [accepted]
PHST- 2012/04/24 06:00 [entrez]
PHST- 2012/04/24 06:00 [pubmed]
PHST- 2012/10/17 06:00 [medline]
AID - S0306-4522(12)00311-9 [pii]
AID - 10.1016/j.neuroscience.2012.03.043 [doi]
PST - ppublish
SO  - Neuroscience. 2012 Jun 28;213:106-11. doi: 10.1016/j.neuroscience.2012.03.043. 
      Epub 2012 Apr 17.