PMID- 22521847
OWN - NLM
STAT- MEDLINE
DCOM- 20120920
LR  - 20120528
IS  - 1873-2518 (Electronic)
IS  - 0264-410X (Linking)
VI  - 30
IP  - 27
DP  - 2012 Jun 8
TI  - Antibody responses following vaccination versus infection in a porcine 
      circovirus-type 2 (PCV2) disease model show distinct differences in virus 
      neutralization and epitope recognition.
PG  - 4079-85
LID - 10.1016/j.vaccine.2012.04.022 [doi]
AB  - Porcine circovirus associated disease (PCVAD) encompasses a group of syndromes 
      linked to infection with porcine circovirus type 2 (PCV2). Based on the 
      hypothesis that the immune responses to vaccination versus infection are 
      quantitatively and qualitatively different, the objective of this study was to 
      evaluate immunity, virus replication and disease protection in pigs vaccinated 
      with PCV2 capsid protein (CP) and during infection. The disease model included 
      dual infection with PCV2 and porcine reproductive and respiratory syndrome virus 
      (PRRSV), a virus known to enhance disease progression and severity. The principal 
      effect of PRRSV infection was to increase peak PCV2 viremia by almost 40-fold; 
      however, PCV2 failed to show a reciprocal effect on PRRSV. In vaccinated pigs, 
      there was no evidence of disease or PCV2 replication following dual virus 
      challenge. Immunity following vaccination favored PCV2 neutralizing activity; 
      whereas, PCV2 infection and disease produced high levels of non-neutralizing 
      antibody, primarily directed against a polypeptide in the C-terminal region of 
      CP. These results support the notion that the magnitude of the total antibody 
      response cannot be used as a measure of protective immunity. Furthermore, 
      protection versus disease lies in the immunodominance of specific epitopes. 
      Epitope specificity should be taken into consideration when designing PCV2 
      vaccines.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Trible, Benjamin R
AU  - Trible BR
AD  - Department of Diagnostic Medicine and Pathobiology, College of Veterinary 
      Medicine, 1800 Denison Ave, Kansas State University, Manhattan, KS 66506, USA.
FAU - Ramirez, Alejandro
AU  - Ramirez A
FAU - Suddith, Andrew
AU  - Suddith A
FAU - Fuller, Alexandra
AU  - Fuller A
FAU - Kerrigan, Maureen
AU  - Kerrigan M
FAU - Hesse, Richard
AU  - Hesse R
FAU - Nietfeld, Jerome
AU  - Nietfeld J
FAU - Guo, Baoqing
AU  - Guo B
FAU - Thacker, Eileen
AU  - Thacker E
FAU - Rowland, Raymond R R
AU  - Rowland RR
LA  - eng
SI  - GENBANK/JQ692110
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20120419
PL  - Netherlands
TA  - Vaccine
JT  - Vaccine
JID - 8406899
RN  - 0 (Antibodies, Neutralizing)
RN  - 0 (Antibodies, Viral)
RN  - 0 (Epitopes)
RN  - 0 (Viral Vaccines)
SB  - IM
MH  - Animals
MH  - Antibodies, Neutralizing/*blood
MH  - Antibodies, Viral/*blood
MH  - Circoviridae Infections/*immunology/virology
MH  - Circovirus/classification/genetics/*immunology
MH  - Coinfection/immunology/virology
MH  - Disease Models, Animal
MH  - Epitopes/immunology
MH  - Molecular Sequence Data
MH  - Porcine respiratory and reproductive syndrome virus/pathogenicity
MH  - Sequence Analysis, DNA
MH  - Swine
MH  - Viral Load
MH  - Viral Vaccines/administration & dosage/*immunology
MH  - Viremia/diagnosis/virology
EDAT- 2012/04/24 06:00
MHDA- 2012/09/21 06:00
CRDT- 2012/04/24 06:00
PHST- 2011/12/17 00:00 [received]
PHST- 2012/03/13 00:00 [revised]
PHST- 2012/04/03 00:00 [accepted]
PHST- 2012/04/24 06:00 [entrez]
PHST- 2012/04/24 06:00 [pubmed]
PHST- 2012/09/21 06:00 [medline]
AID - S0264-410X(12)00544-0 [pii]
AID - 10.1016/j.vaccine.2012.04.022 [doi]
PST - ppublish
SO  - Vaccine. 2012 Jun 8;30(27):4079-85. doi: 10.1016/j.vaccine.2012.04.022. Epub 2012 
      Apr 19.