PMID- 22523259
OWN - NLM
STAT- MEDLINE
DCOM- 20121107
LR  - 20120712
IS  - 1537-6591 (Electronic)
IS  - 1058-4838 (Linking)
VI  - 55
IP  - 3
DP  - 2012 Aug
TI  - Clinical Sindbis alphavirus infection is associated with HLA-DRB1*01 allele and 
      production of autoantibodies.
PG  - 358-63
LID - 10.1093/cid/cis405 [doi]
AB  - BACKGROUND: Sindbis virus (SINV) is a mosquito-borne alphavirus found in Eurasia, 
      Africa, and Oceania. Clinical SINV infection, characterized by arthropathic 
      disease that may persist for years, is primarily reported in Northern Europe 
      where the disease has considerable public health importance in endemic areas. The 
      aim of this study was to investigate the role of genetic factors in the 
      susceptibility and outcome of SINV infection and to elucidate the association 
      between SINV infection and autoimmunity. METHODS: The study included 49 patients 
      with serologically confirmed symptomatic SINV infection who were followed for 3 
      years after acute infection. Human leukocyte antigen (HLA) genes known to be 
      associated with rheumatic and infectious diseases and complement C4 genes were 
      determined in 35 patients. Furthermore, a set of autoantibodies was measured at 
      the acute phase and 3 years after infection in 44 patients. RESULTS: The 
      frequency of DRB1*01 was significantly higher among patients with SINV infection 
      than in the reference population (odds ratio, 3.3; 95% confidence interval, 
      1.7-6.5; P = .003). The DRB1*01 allele was particularly frequent in patients who 
      at 3 years postinfection experienced joint manifestations. The frequency of 
      rheumatoid factor at 3 years postinfection was 29.5% and had increased 
      significantly (P = .02) during the 3-year period. In addition, antinuclear and 
      antimitochondrial antibodies were present in serum 3 years postinfection with 
      frequencies of 15.9% and 6.8%, respectively. CONCLUSIONS: Our data show that 
      symptomatic SINV infection is associated with the HLA system and that 
      autoantibody titers are elevated in patients 3 years postinfection. These 
      findings indicate that SINV-induced arthritis shares features with autoimmune 
      diseases.
FAU - Sane, Jussi
AU  - Sane J
AD  - Infection Biology Research Program, Department of Virology, Haartman Institute, 
      Faculty of Medicine, University of Helsinki, Finland. jussi.sane@helsinki.fi
FAU - Kurkela, Satu
AU  - Kurkela S
FAU - Lokki, Marja-Liisa
AU  - Lokki ML
FAU - Miettinen, Aaro
AU  - Miettinen A
FAU - Helve, Tapani
AU  - Helve T
FAU - Vaheri, Antti
AU  - Vaheri A
FAU - Vapalahti, Olli
AU  - Vapalahti O
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120420
PL  - United States
TA  - Clin Infect Dis
JT  - Clinical infectious diseases : an official publication of the Infectious Diseases 
      Society of America
JID - 9203213
RN  - 0 (Autoantibodies)
RN  - 0 (Complement C4)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - Alphavirus Infections/*genetics/*immunology
MH  - Autoantibodies/*blood
MH  - Child
MH  - Complement C4/genetics
MH  - Europe
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - HLA-DRB1 Chains/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Sindbis Virus/*immunology
MH  - Young Adult
EDAT- 2012/04/24 06:00
MHDA- 2012/11/08 06:00
CRDT- 2012/04/24 06:00
PHST- 2012/04/24 06:00 [entrez]
PHST- 2012/04/24 06:00 [pubmed]
PHST- 2012/11/08 06:00 [medline]
AID - cis405 [pii]
AID - 10.1093/cid/cis405 [doi]
PST - ppublish
SO  - Clin Infect Dis. 2012 Aug;55(3):358-63. doi: 10.1093/cid/cis405. Epub 2012 Apr 
      20.