PMID- 22523955
OWN - NLM
STAT- MEDLINE
DCOM- 20120515
LR  - 20190715
IS  - 1533-4880 (Print)
IS  - 1533-4880 (Linking)
VI  - 12
IP  - 1
DP  - 2012 Jan
TI  - A novel magnetic nanoparticle hyperthermia combined with ACMF-dependant drug 
      release by DAMMs injection in VX-2 liver tumors.
PG  - 127-31
AB  - In this paper, we investigated the feasibility and effect of a novel combination 
      therapy of magnetic nanoparticles (MNPs) hyperthermia with anticancer drugs for 
      solid malignancies using doxorubicin-loaded alginate-templated magnetic 
      microcapsules (DAMMs) in an animal liver cancer model. Firstly, DAMMs containing 
      18 nm gamma-Fe2O3 with doxorubicin (Dox) were synthesized and characterized. 
      Then, the particular behavior of Dox release under external alternating current 
      magnetic filed (ACMF) was tested in vitro. Moreover, to obtain accurate 
      thermotherapy, the dose of DAMMs and temperature rise were computed by 
      Hyperthermia treatment plan (HTP) and a fiber optic temperature sensor (FOTS) was 
      used to monitor the temperature rise during treatments on VX-2 liver 
      tumor-bearing rabbits. Furthermore, the therapeutic effect was studied by 
      histopathological examinations and animal survival. The results showed that ACMF 
      can induce Dox fast release during the treatment and the high MNPs content of 
      DMMAs guaranteed the temperature rise for hyperthermia in tumors. The rabbits 
      bearing VX-2 tumors in the magnetic hyperthermia using DMMAs group gained the 
      most tumor necrosis and survival time. It was indicated that DAMMs-based magnetic 
      hyperthermia could be a feasible and effective remedy which could be targeted at 
      liver tumors by dual effects of hyperthermia and chemotherapy.
FAU - Zhang, Quanan
AU  - Zhang Q
AD  - Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210029, China.
FAU - Tong, Jinlong
AU  - Tong J
FAU - Chen, Huijuan
AU  - Chen H
FAU - Jiang, Linlin
AU  - Jiang L
FAU - Zhu, Huiping
AU  - Zhu H
FAU - Zhu, Xiaofang
AU  - Zhu X
FAU - Yu, Hui
AU  - Yu H
FAU - Liu, Jiwei
AU  - Liu J
FAU - Liu, Baorui
AU  - Liu B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Nanosci Nanotechnol
JT  - Journal of nanoscience and nanotechnology
JID - 101088195
RN  - 0 (Antibiotics, Antineoplastic)
RN  - 0 (Magnetite Nanoparticles)
RN  - 0 (Nanocapsules)
RN  - 80168379AG (Doxorubicin)
SB  - IM
MH  - Animals
MH  - Antibiotics, Antineoplastic/administration & dosage
MH  - Cell Line, Tumor
MH  - Combined Modality Therapy
MH  - Doxorubicin/*administration & dosage
MH  - Hyperthermia, Induced/*methods
MH  - Liver Neoplasms/pathology/*therapy
MH  - Magnetite Nanoparticles/*therapeutic use
MH  - Nanocapsules/*therapeutic use
MH  - Rabbits
MH  - Treatment Outcome
EDAT- 2012/04/25 06:00
MHDA- 2012/05/16 06:00
CRDT- 2012/04/25 06:00
PHST- 2012/04/25 06:00 [entrez]
PHST- 2012/04/25 06:00 [pubmed]
PHST- 2012/05/16 06:00 [medline]
AID - 10.1166/jnn.2012.5118 [doi]
PST - ppublish
SO  - J Nanosci Nanotechnol. 2012 Jan;12(1):127-31. doi: 10.1166/jnn.2012.5118.