PMID- 22524201
OWN - NLM
STAT- MEDLINE
DCOM- 20120920
LR  - 20120619
IS  - 1600-0412 (Electronic)
IS  - 0001-6349 (Linking)
VI  - 91
IP  - 7
DP  - 2012 Jul
TI  - Preimplantation genetic diagnosis with HLA matching - a way to save a child.
PG  - 765-8
LID - 10.1111/j.1600-0412.2012.01426.x [doi]
AB  - Preimplantation genetic diagnosis can be used to establish a pregnancy with an 
      embryo that is human leukocyte antigen (HLA)-matched to a sibling having a 
      hematological or immunological disease and needing a life-saving bone marrow 
      transplantation. The ethical aspects of this procedure have been discussed 
      intensively. The procedure applies where no unrelated HLA-matching donor is 
      available or when transplantation from an HLA-matching sibling is considered a 
      better solution. It is only offered in a limited number of centers in Europe as 
      this is a challenging procedure. Where both HLA matching and diagnosis of a 
      dominant disease are necessary, only a small proportion of the embryos can be 
      used, and the procedure is not always technically feasible. The clinical 
      pregnancy rate per cycle started is much lower than following normal in vitro 
      fertilization (IVF) due to a high cycle cancellation rate, but the success rate 
      is only somewhat lower when measured per transfer.
CI  - (c) 2012 The Authors Acta Obstetricia et Gynecologica Scandinavica(c) 2012 Nordic 
      Federation of Societies of Obstetrics and Gynecology.
FAU - Ingerslev, Hans Jakob
AU  - Ingerslev HJ
AD  - Fertility Clinic/Center for Preimplantation Genetic Diagnosis, Aarhus University 
      Hospital, Aarhus, Denmark. jakob.ingerslev@skejby.rm.dk
FAU - Hindkjaer, Johnny
AU  - Hindkjaer J
LA  - eng
PT  - Journal Article
DEP - 20120522
PL  - United States
TA  - Acta Obstet Gynecol Scand
JT  - Acta obstetricia et gynecologica Scandinavica
JID - 0370343
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Bone Marrow Transplantation/immunology
MH  - Female
MH  - HLA Antigens/*genetics/*immunology
MH  - Histocompatibility Testing/ethics/*methods
MH  - Humans
MH  - Infant, Newborn
MH  - Pregnancy
MH  - Preimplantation Diagnosis/ethics/*methods
MH  - Siblings
EDAT- 2012/04/25 06:00
MHDA- 2012/09/21 06:00
CRDT- 2012/04/25 06:00
PHST- 2012/04/25 06:00 [entrez]
PHST- 2012/04/25 06:00 [pubmed]
PHST- 2012/09/21 06:00 [medline]
AID - 10.1111/j.1600-0412.2012.01426.x [doi]
PST - ppublish
SO  - Acta Obstet Gynecol Scand. 2012 Jul;91(7):765-8. doi: 
      10.1111/j.1600-0412.2012.01426.x. Epub 2012 May 22.