PMID- 22526543
OWN - NLM
STAT- MEDLINE
DCOM- 20131028
LR  - 20211021
IS  - 1432-2072 (Electronic)
IS  - 0033-3158 (Print)
IS  - 0033-3158 (Linking)
VI  - 226
IP  - 4
DP  - 2013 Apr
TI  - Effects of the kappa opioid receptor antagonist, norbinaltorphimine, on stress 
      and drug-induced reinstatement of nicotine-conditioned place preference in mice.
PG  - 763-8
LID - 10.1007/s00213-012-2716-y [doi]
AB  - RATIONALE: Several studies implicate stress as a risk factor for the development 
      and maintenance of drug addictive behaviors and drug relapse. Kappa opioid 
      receptor (KOR) antagonists have been shown to attenuate behavioral responses to 
      stress and stress-induced reinstatement of cocaine and ethanol seeking and 
      preference. OBJECTIVES: In the current study, we determined whether the selective 
      KOR antagonist, norbinaltorphimine (nor-BNI), would block stress-induced 
      reinstatement of nicotine preference. METHODS: Adult Institute of Cancer Research 
      mice were conditioned with 0.5 mg/kg nicotine, injected subcutaneously (s.c.) for 
      3 days and tested in the nicotine-conditioned place preference (CPP) model. After 
      3 days extinction, nor-BNI (10 mg/kg, s.c.) was administered 16 h prior to a 
      priming dose of nicotine (0.1 mg/kg, s.c.), and mice were tested in the CPP model 
      for nicotine-induced reinstatement of CPP. A separate group of mice was subjected 
      to a 2-day modified forced swim test (FST) paradigm to induce stress after 3 days 
      extinction from CPP. Mice were given vehicle or nor-BNI (10 mg/kg, s.c.) 16 h 
      prior to each FST session. RESULTS: Nor-BNI pretreatment significantly attenuated 
      stress-induced reinstatement of nicotine-CPP, but had no effect on 
      nicotine-primed reinstatement. CONCLUSIONS: Blockade of KORs by selective 
      antagonists attenuates stress-induced reinstatement of nicotine-CPP. Overall, the 
      kappa opioid system may serve as a therapeutic target for suppressing multiple 
      signaling processes which contribute to maintenance of smoking, smoking relapse, 
      and drug abuse in general.
FAU - Jackson, K J
AU  - Jackson KJ
AD  - Department of Psychiatry, Virginia Commonwealth University, Richmond, VA 23219, 
      USA.
FAU - McLaughlin, J P
AU  - McLaughlin JP
FAU - Carroll, F I
AU  - Carroll FI
FAU - Damaj, M I
AU  - Damaj MI
LA  - eng
GR  - R01 DA012610/DA/NIDA NIH HHS/United States
GR  - T32 MH020030/MH/NIMH NIH HHS/United States
GR  - MH-020030/MH/NIMH NIH HHS/United States
GR  - DA-12610/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20120420
PL  - Germany
TA  - Psychopharmacology (Berl)
JT  - Psychopharmacology
JID - 7608025
RN  - 0 (Narcotic Antagonists)
RN  - 0 (Receptors, Opioid, kappa)
RN  - 36OOQ86QM1 (norbinaltorphimine)
RN  - 5S6W795CQM (Naltrexone)
RN  - 6M3C89ZY6R (Nicotine)
SB  - IM
MH  - Animals
MH  - Conditioning, Psychological/drug effects
MH  - Disease Models, Animal
MH  - Extinction, Psychological
MH  - Male
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Naltrexone/*analogs & derivatives/pharmacology
MH  - Narcotic Antagonists/*pharmacology
MH  - Nicotine/*administration & dosage
MH  - Receptors, Opioid, kappa/antagonists & inhibitors
MH  - Recurrence
MH  - Risk Factors
MH  - Self Administration
MH  - Smoking/epidemiology
MH  - Stress, Psychological/*psychology
PMC - PMC3821839
MID - NIHMS522968
COIS- Conflict of interest There are no conflicts of interest to disclose for this 
      research. The experiments in the current studies comply with the current laws in 
      the country in which they were performed.
EDAT- 2012/04/25 06:00
MHDA- 2013/10/29 06:00
PMCR- 2013/11/08
CRDT- 2012/04/25 06:00
PHST- 2012/02/04 00:00 [received]
PHST- 2012/03/31 00:00 [accepted]
PHST- 2012/04/25 06:00 [entrez]
PHST- 2012/04/25 06:00 [pubmed]
PHST- 2013/10/29 06:00 [medline]
PHST- 2013/11/08 00:00 [pmc-release]
AID - 10.1007/s00213-012-2716-y [doi]
PST - ppublish
SO  - Psychopharmacology (Berl). 2013 Apr;226(4):763-8. doi: 10.1007/s00213-012-2716-y. 
      Epub 2012 Apr 20.