PMID- 22526925
OWN - NLM
STAT- MEDLINE
DCOM- 20121108
LR  - 20211021
IS  - 1573-3017 (Electronic)
IS  - 0963-9292 (Linking)
VI  - 21
IP  - 5
DP  - 2012 Jul
TI  - Divergent teratogenicity of agonists of retinoid X receptors in embryos of 
      zebrafish (Danio rerio).
PG  - 1465-75
LID - 10.1007/s10646-012-0900-9 [doi]
AB  - Zebrafish (Danio rerio) embryos were comparably exposed to seven known agonists 
      of retinoid X receptors (RXRs) including two endogenous compounds (9-cis-retinoic 
      acid and docosahexaenoic acid), four man-made selective ligands (LGD1069, 
      SR11237, fluorobexarotene and CD3254), and a biocide (triphenyltin). The dominant 
      phenotypes of malformation were sharp mouths and small caudal fins in 1 mg/L 
      SR11237-treated group after 5 days exposure. 9-cis-retinoic acid and LGD1069 
      induced multiple malformations including small eyes, bent notochords, reduced 
      brain, enlarged proctodaems, absence of fins, short tails and edema after 5 days 
      exposure. Fluorobexarotene and CD3254 induced similar phenotypes of malformations 
      after 5 days exposure at low concentration (20 mug/L) to those after the 1st d 
      exposure at high concentrations (50 and 100 mug/L). Triphenlytin induced multiple 
      malformations including deformed eyes, bent notochords, bent tails, and edema in 
      hearts after 5 days exposure at concentrations of 1-10 mug Sn/L. In contrast, no 
      discernible malformations were observed in triphenlytin-treated groups after each 
      separate day exposure. These agonists not only showed different ability of 
      teratogenicity but also induced different phenotypes of malformation in zebrafish 
      embryos. In addition, the sensitive stages of zebrafish embryos were different in 
      response to these agonists. Therefore, our results suggest that the agonists of 
      RXRs had divergent teratogenicity in zebrafish embryos.
FAU - Shi, Huahong
AU  - Shi H
AD  - State Key Laboratory of Estuarine and Coastal Research, East China Normal 
      University, Shanghai 200062, China. hhshi@des.ecnu.edu.cn
FAU - Zhu, Pan
AU  - Zhu P
FAU - Sun, Zhi
AU  - Sun Z
FAU - Yang, Bo
AU  - Yang B
FAU - Zheng, Liang
AU  - Zheng L
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120410
PL  - United States
TA  - Ecotoxicology
JT  - Ecotoxicology (London, England)
JID - 9885956
RN  - 0 (Organotin Compounds)
RN  - 0 (Retinoid X Receptors)
RN  - 0 (Teratogens)
RN  - 0 (Water Pollutants, Chemical)
RN  - 5352-74-9 (9,13-retinoic acid)
RN  - 5688UTC01R (Tretinoin)
RN  - 95T92AGN0V (triphenyltin)
SB  - IM
MH  - Animals
MH  - Embryo, Nonmammalian/*drug effects
MH  - Environmental Exposure/*adverse effects/analysis
MH  - Female
MH  - Male
MH  - Organotin Compounds/toxicity
MH  - Phenotype
MH  - Retinoid X Receptors/*agonists
MH  - Teratogens/analysis/*toxicity
MH  - Tretinoin/analogs & derivatives/toxicity
MH  - Water Pollutants, Chemical/analysis/*toxicity
MH  - Zebrafish/embryology/*growth & development
EDAT- 2012/04/25 06:00
MHDA- 2012/11/09 06:00
CRDT- 2012/04/25 06:00
PHST- 2012/03/27 00:00 [accepted]
PHST- 2012/04/25 06:00 [entrez]
PHST- 2012/04/25 06:00 [pubmed]
PHST- 2012/11/09 06:00 [medline]
AID - 10.1007/s10646-012-0900-9 [doi]
PST - ppublish
SO  - Ecotoxicology. 2012 Jul;21(5):1465-75. doi: 10.1007/s10646-012-0900-9. Epub 2012 
      Apr 10.