PMID- 22527238 OWN - NLM STAT- MEDLINE DCOM- 20130822 LR - 20211021 IS - 1432-1459 (Electronic) IS - 0340-5354 (Linking) VI - 259 IP - 11 DP - 2012 Nov TI - A novel prognostic marker in acute ischemic stroke: small pericardial effusion. PG - 2354-9 LID - 10.1007/s00415-012-6501-y [doi] AB - The study aimed to evaluate the prognostic importance of small pericardial effusion (SPE) found on echocardiography in a cohort of patients hospitalized for acute ischemic stroke. We prospectively followed a series of 408 consecutive first-ever acute ischemic stroke patients aged >/=50 years who were admitted to the hospital within 24 h of the onset of stroke symptoms. All of the patients underwent transthoracic echocardiography within the first 48 h. Exclusion criteria were cardiothoracic surgery or acute myocardial infarction within the previous 6 months, a moderate or greater pericardial effusion (>1 cm if circumferential), and inadequate visualization of the pericardial space. The patients were followed for 1 year or until death, whichever came first. SPE was noted in 64 (15.7 %) of the patients. Mortality at 1 year was greater for patients with a small effusion (n = 21, 32.8 %) compared to those without an effusion (n = 40, 11.6 %, p < 0.001). After adjustment for age, demographics, medical history, and other echocardiographic findings, SPE remained associated with higher mortality (OR 2.515; 95 % CI 1.188-5.477; p = 0.008). This study is the first to demonstrate that the presence of SPE is associated with increased mortality in patients with first-ever acute ischemic stroke. FAU - Biteker, Murat AU - Biteker M AD - Department of Cardiology, Haydarpasa Numune Education and Research Hospital, Tibbiye Cad. No. 40, Uskudar, Istanbul, Turkey. murbit2@yahoo.com FAU - Tekkesin, Ahmet Ilker AU - Tekkesin AI FAU - Dayan, Akin AU - Dayan A FAU - Misirli, Cemile Handan AU - Misirli CH LA - eng PT - Journal Article DEP - 20120419 PL - Germany TA - J Neurol JT - Journal of neurology JID - 0423161 RN - 0 (Biomarkers) SB - IM MH - Aged MH - Aged, 80 and over MH - Biomarkers MH - Brain Ischemia/*diagnostic imaging/*mortality MH - Cohort Studies MH - Echocardiography/methods MH - Female MH - Follow-Up Studies MH - Humans MH - Male MH - Middle Aged MH - Pericardial Effusion/*diagnostic imaging/*mortality MH - Prognosis MH - Prospective Studies MH - Stroke/*diagnostic imaging/*mortality EDAT- 2012/04/25 06:00 MHDA- 2013/08/24 06:00 CRDT- 2012/04/25 06:00 PHST- 2012/03/11 00:00 [received] PHST- 2012/03/27 00:00 [accepted] PHST- 2012/04/25 06:00 [entrez] PHST- 2012/04/25 06:00 [pubmed] PHST- 2013/08/24 06:00 [medline] AID - 10.1007/s00415-012-6501-y [doi] PST - ppublish SO - J Neurol. 2012 Nov;259(11):2354-9. doi: 10.1007/s00415-012-6501-y. Epub 2012 Apr 19.