PMID- 22528664
OWN - NLM
STAT- MEDLINE
DCOM- 20130107
LR  - 20120828
IS  - 1552-4965 (Electronic)
IS  - 1549-3296 (Linking)
VI  - 100
IP  - 10
DP  - 2012 Oct
TI  - In vitro assessment of poly(methylmethacrylate)-based bone cement containing 
      magnetite nanoparticles for hyperthermia treatment of bone tumor.
PG  - 2537-45
LID - 10.1002/jbm.a.34185 [doi]
AB  - Poly(methylmethacrylate) (PMMA)-based cements containing magnetite 
      (C-PMMA/Fe(3)O(4)) is useful in hyperthermia treatment for bone tumor. We have 
      prepared C-PMMA/Fe(3)O(4) by incorporating Fe(3) O(4) powders of different 
      diameters (means of 300, 35, and 11 nm) into the polymerization reaction of 
      methyl methacrylate monomer to develop a new bone cement with high heating 
      efficiencies in alternating current (AC) magnetic fields. Further, we have 
      investigated the in vitro heating capability of the cements in different AC 
      magnetic fields. The mechanical strength and biocompatibility of the resultant 
      cements were also assessed. Their heat generation strongly depends on the 
      magnetite nanoparticle sizes and applied magnetic fields. The cement containing 
      Fe(3)O(4) with mean diameter around 35 nm exhibited the highest heating 
      capability in AC magnetic fields of 120 and 300 Oe at 100 kHz while that with 
      mean diameter around 11 nm exhibited optimum heating capability in AC magnetic 
      fields of 40 Oe at 600 kHz. The incorporation of Fe(3)O(4) into cement-30 wt % of 
      the total amount of cement-did not significantly change the compressive strength 
      of cement, and the proliferation of rat fibroblast Rat-1 cells on cement discs 
      was not inhibited. Our investigations are useful for designing new PMMA/Fe(3)O(4) 
      bone cement with high heating efficiencies and biocompatibilities for bone tumor 
      treatments.
CI  - Copyright (c) 2012 Wiley Periodicals, Inc.
FAU - Li, Zhixia
AU  - Li Z
AD  - College of Chemistry and Chemical Engineering, Guangxi University, Nanning 
      530004, China. zhixiali@hotmail.com
FAU - Kawamura, Koki
AU  - Kawamura K
FAU - Kawashita, Masakazu
AU  - Kawashita M
FAU - Kudo, Tada-aki
AU  - Kudo TA
FAU - Kanetaka, Hiroyasu
AU  - Kanetaka H
FAU - Hiraoka, Masahiro
AU  - Hiraoka M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120424
PL  - United States
TA  - J Biomed Mater Res A
JT  - Journal of biomedical materials research. Part A
JID - 101234237
RN  - 0 (Biocompatible Materials)
RN  - 0 (Bone Cements)
RN  - 0 (Magnetite Nanoparticles)
RN  - 9007-49-2 (DNA)
RN  - 9011-14-7 (Polymethyl Methacrylate)
SB  - IM
MH  - Animals
MH  - Biocompatible Materials/pharmacology
MH  - Bone Cements/*pharmacology
MH  - Bone Neoplasms/*therapy
MH  - DNA/metabolism
MH  - Electricity
MH  - Fibroblasts/drug effects/metabolism
MH  - Hot Temperature
MH  - *Hyperthermia, Induced
MH  - Magnetic Fields
MH  - Magnetite Nanoparticles/*therapeutic use/ultrastructure
MH  - Materials Testing
MH  - Mechanical Phenomena/drug effects
MH  - Polymethyl Methacrylate/*pharmacology
MH  - Rats
MH  - X-Ray Diffraction
EDAT- 2012/04/25 06:00
MHDA- 2013/01/08 06:00
CRDT- 2012/04/25 06:00
PHST- 2011/09/18 00:00 [received]
PHST- 2012/02/26 00:00 [revised]
PHST- 2012/03/12 00:00 [accepted]
PHST- 2012/04/25 06:00 [entrez]
PHST- 2012/04/25 06:00 [pubmed]
PHST- 2013/01/08 06:00 [medline]
AID - 10.1002/jbm.a.34185 [doi]
PST - ppublish
SO  - J Biomed Mater Res A. 2012 Oct;100(10):2537-45. doi: 10.1002/jbm.a.34185. Epub 
      2012 Apr 24.