PMID- 22529691
OWN - NLM
STAT- MEDLINE
DCOM- 20121011
LR  - 20220311
IS  - 2219-2840 (Electronic)
IS  - 1007-9327 (Print)
IS  - 1007-9327 (Linking)
VI  - 18
IP  - 14
DP  - 2012 Apr 14
TI  - No evidence of circulating autoantibodies against osteoprotegerin in patients 
      with celiac disease.
PG  - 1622-7
LID - 10.3748/wjg.v18.i14.1622 [doi]
AB  - AIM: To investigate risk factors for low bone mineral density (BMD) in celiac 
      disease (CD) patients, focusing on circulating autoantibodies against 
      osteoprotegerin (OPG). METHODS: Seventy asymptomatic CD adult patients on 
      gluten-free diet (GFD) and harbouring persistent negative CD-related serology 
      were recruited. Conventional risk factors for osteoporosis (e.g., age, sex, 
      menopausal status, history of fractures, smoke, and body mass index) were checked 
      and BMD was assessed by dual energy X ray absorptiometry. Serum calcium and 
      parathyroid hormone (PTH) levels were evaluated. Thirty-eight patients underwent 
      repeat duodenal biopsy. Serum samples from a selected sub-group of 30 patients, 
      who were also typed for human leukocyte antigen (HLA) DQ2 and DQ8 haplotype, were 
      incubated with homodimeric recombinant human OPG and tested by western blotting 
      with an anti-OPG antibody after immunoprecipitation. RESULTS: Despite persistent 
      negative CD-related serology and strict adherence to GFD, 49 out of the 70 (74%) 
      patients displayed low BMD. Among these patients, 13 (24%) showed osteoporosis 
      and 36 (76%) osteopenia. With the exception of age, conventional risk factors for 
      osteoporosis did not differ between patients with normal and low BMD. Circulating 
      serum calcium and PTH levels were normal in all patients. Duodenal mucosa healing 
      was found in 31 (82%) out of 38 patients who underwent repeat duodenal biopsy 
      with 20 (64%) still displaying low BMD. The remaining 7 patients had an 
      incomplete normalization of duodenal mucosa with 6 (84%) showing low BMD. No 
      evidence of circulating antibodies against OPG was found in the serum of 30 
      celiac patients who were tested for, independent of BMD, duodenal histology, and 
      HLA status. CONCLUSION: If any, the role of circulating autoantibodies against 
      OPG in the pathogenesis of bone derangement in patients with CD is not a major 
      one.
FAU - Larussa, Tiziana
AU  - Larussa T
AD  - Department of Health Science, University of Catanzaro "Magna Graecia", 88100 
      Catanzaro, Italy.
FAU - Suraci, Evelina
AU  - Suraci E
FAU - Nazionale, Immacolata
AU  - Nazionale I
FAU - Leone, Isabella
AU  - Leone I
FAU - Montalcini, Tiziana
AU  - Montalcini T
FAU - Abenavoli, Ludovico
AU  - Abenavoli L
FAU - Imeneo, Maria
AU  - Imeneo M
FAU - Pujia, Arturo
AU  - Pujia A
FAU - Luzza, Francesco
AU  - Luzza F
LA  - eng
PT  - Journal Article
PL  - United States
TA  - World J Gastroenterol
JT  - World journal of gastroenterology
JID - 100883448
RN  - 0 (Autoantibodies)
RN  - 0 (Osteoprotegerin)
RN  - 0 (TNFRSF11B protein, human)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Autoantibodies/*immunology
MH  - Bone Diseases, Metabolic/complications/*immunology
MH  - Calcium/metabolism
MH  - Celiac Disease/complications/*immunology
MH  - Diet, Gluten-Free
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Osteoporosis/complications/*immunology
MH  - Osteoprotegerin/*immunology
PMC - PMC3325528
OTO - NOTNLM
OT  - Bone mineral density
OT  - Celiac disease
OT  - Gluten-free diet
OT  - Osteopenia
OT  - Osteoporosis
OT  - Osteoprotegerin
EDAT- 2012/04/25 06:00
MHDA- 2012/10/12 06:00
PMCR- 2012/04/14
CRDT- 2012/04/25 06:00
PHST- 2011/09/22 00:00 [received]
PHST- 2012/02/20 00:00 [revised]
PHST- 2012/02/26 00:00 [accepted]
PHST- 2012/04/25 06:00 [entrez]
PHST- 2012/04/25 06:00 [pubmed]
PHST- 2012/10/12 06:00 [medline]
PHST- 2012/04/14 00:00 [pmc-release]
AID - 10.3748/wjg.v18.i14.1622 [doi]
PST - ppublish
SO  - World J Gastroenterol. 2012 Apr 14;18(14):1622-7. doi: 10.3748/wjg.v18.i14.1622.